Pregnancy outcome following gestational exposure to organic solvents a prospective controlled study

4 PREGNANCY OUTCOME FOLLOWING GESTATIONAL EXPOSURE TO ORGANIC SOLVENTS A PROSPECTIVE CONTROLLED STUDY 

The Motherisk Program at the Hospital for Sick Children was the first to prospectively evaluate pregnancy and fetal outcome following maternal occupational exposure to organic solvents with malformations being the primary outcome of interest.  

The study group consisted of all pregnant women occupationally exposed to organic solvents and counseled between 1987-1996 by the Motherisk Program at the Hospital for Sick Children. Details concerning the time of exposure to organic solvents were recorded for de- 

The primary outcome of interest was major malfomiations. A major malformation was defined as any anomaly that has an adverse effect on either die function or the social acceptability of the child. The expected rate of major malformations is between 1% to 3%. 

The Motherisk protocol allowed us to record in a systematic manner all exposure data and other maternal and paternal medical details at the time of exposure during the first trimester of pregnancy and to follow up pregnancy outcomes prospectively in this eohort. The control group was assessed in an identical manner. 

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Khattak, S., K-Moghtader, G., McMartin, K., Barrera, M., Kennedy, D., Koren, G. (1999). Pregnancy outcome following gestational exposure to organic solvents a prospective controlled study. J. Amer. Med. Assoc. 281 1106—1109. 

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