Preclinical Safety Assessment of Drug Candidate-Induced Pancreatic Toxicity From an Applied Perspective

PRECLINICAL SAFETY ASSESSMENT OF DRUG CANDIDATE-INDUCED PANCREATIC TOXICITY FROM AN APPLIED PERSPECTIVE 

Karrie a. Brenneman Shashi K. Ramaiah and Lauren M. Gauthier  

Drug Discovery Toxicology From Target Assessment to Translational Biomarkers, First Edition. Edited by Y vonne Will, J. Eric McDuffie, Andrew J. Olaharski, and Brandon D. Jeffy. 

FIGURE 17.1 Microscopic appearance of the normal rat pancreas. An islet of endocrine cells is surrounded by acinar cells of the exocrine pancreas in a normal rat. A, arteriole AC, acinar cells D, ductule 1, islet V, venule ZG, zymogen granules. (H E stain original magnification 200x) (See insert for color representation of the figure.) 

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