Prazosin Verapamil

Harrison, P.M. Tonkin, A.M. McLean, A.J. Simple and rapid analysis of atenolol and metoprolol in plasma using solid-phase extraction and high-performance liquid chromatography. J.Chromatogr, 1985, 339, 429-433 [plasma SPE fluorescence detection LOD 10 ng/mL non-interfering chlorothiazide, disopyramide, furosemide, hydralazine, lidocaine, methydopa, prazosin, verapamil simultaneous alprenolol, oxprenolol, pindolol, practolol, propranolol, timolol]... 

Ditropan XL Procardia XL Glucotrol XL Alpress XL (France) Cardura XL (Germany) Concerta Covera HS DynaCirc CR Oxybutynin chloride Nifedipine Glipizide Prazosin Doxazosin mesylate Methylphenidate HC1 Verapamil HC1 Isradipine... 

Fig. 4 Venn-diagram for selected compounds interacting with the key MDR-related ABC transporters. MDR-Modulating agents. Abbreviations CSA cyclosporin A, VERAP verapamil STAURO staurosporine, ECON econazole, PRAZ prazosine, FTC fumitremor-gin C, PROB probenecide, BBR benzbromarone, SUPYR sulfinpyrazone, INDOM in-domethacin, GENIS genistein, PGA2 prostaglandin A2, CCCP chlorocarbonyl cyanide phenylhydrazine. (Reproduced from [4])...

An interaction of prazosin with nifedipine or verapamil resulted in acute hypotension (203,204). The mechanism appears to be partly kinetic (the systemic availability of prazosin increasing by 60%) and partly dynamic. 

Pasanisi F, Meredith PA, Elliott HL, Reid JL. Verapamil and prazosin pharmacodynamic and pharmacokinetic interactions in normal man. Br J Clin Pharmacol 1984 18 290P. 

Thaliporphine (0.1-100 pM), a potent vasoconstrictor, was observed to produce contractions in the isolated guinea-pig ileum in a concentration-dependent manner. These contractions were not affected by pretreatment of the ileum with tetrodotoxin, phentolamine, prazosin, propranolol, naloxone, atropine, diphenhydramine, methysergide, indomethacin or staurosporine. However, the contraction was markedly inhibited by nifedipine and verapamil, suggesting that thaliporphine produces intestinal smooth muscle contraction by a direct effect on muscle mediated by an increased Ca+2 influx through voltage-dependent Ca+2 channels [327]. 

Octi Acyclovir, AZT, ganciclovir, indinavir, ritonavir, nelfinavir, saquinavir, amantandine, desipramine, nicotine, procainamide, vecuronium, cimetidine, clonidine, prazosin, reserpine, verapamil... 

Drugs or pharmacological interventions (heparin (Berger and Zaret 1984), antimicrobials or antibiotics, anticonvulsants, tranquilizers, anti-inflammatory agents (Chervu et al. 1981 Hladik et al. 1982), nifedipine (Sampson 1993), prazosin, digoxin (Lee 1983), propanolol, hydralazine, methyldopa, verapamil, chlorothiazide, furosemide, ranitidine, iron therapy, etoposide-h doxontbicin (Sampson 1993, 1995), others)... 

Also analyzed acebutolol, acepromazine, acetaminophen, acetazolamide, acetophenazine, albuterol, amitriptyline, amobarbital, amoxapine, antipsrrine, atenolol, atropine, azata-dine, baclofen, benzocaine, bromocriptine, brompheniramine, brotizolam, bupivacaine, buspirone, butabarbital, butalbital, caffeine, carbamazepine, cetirizine, chlorqyclizine, chlordiazepoxide, chlormezanone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, chlorprothixene, chlorthalidone, chlorzoxazone, cimetidine, cisapride, clomipramine, clonazepam, clonidine, clozapine, cocaine, codeine, colchicine, qyclizine, (yclo-benzaprine, dantrolene, desipramine, diazepam, diclofenac, diflunisal, diltiazem, diphenhydramine, diphenidol, dipheno late, dipyridamole, disopyramide, dobutamine, doxapram, doxepin, droperidol, encainide, ethidium bromide, ethopropazine, fenoprofen, fentanyl, flavoxate, fluoxetine, fluphenazine, flurazepam, flurbiprofen, fluvoxamine, fii-rosemide, glutethimide, glyburide, guaifenesin, haloperidol, homatropine, hydralazine, hydrochlorothiazide, hydrocodone, hydromorphone, hydro g chloroquine, hydroxyzine, ibuprofen, imipramine, indomethacin, ketoconazole, ketoprofen, ketorolac, labetalol, le-vorphanol, lidocaine, loratadine, lorazepam, lovastatin, loxapine, mazindol, mefenamic acid, meperidine, mephenytoin, mepivacaine, mesoridazine, metaproterenol, methadone, methdilazine, methocarbamol, methotrexate, methotrimeprazine, methoxamine, methyl-dopa, methylphenidate, metoclopramide, metolazone, metoprolol, metronidazole, midazolam, moclobemide, morphine, nadolol, nalbuphine, naloxone, naphazoline, naproxen, nifedipine, nizatidine, norepinephrine, nortriptyline, oxazepam, oxycodone, oxymetazo-line, paroxetine, pemoline, pentazocine, pentobarbital, pentoxifylline, perphenazine, pheniramine, phenobarbital, phenol, phenolphthalein, phentolamine, phenylbutazone, phenyltoloxamine, phenytoin, pimozide, pindolol, piroxicam, pramoxine, prazepam, prazosin, probenecid, procainamide, procaine, prochlorperazine, procyclidine, promazine, promethazine, propafenone, propantheline, propiomazine, propofol, propranolol, protriptyline, quazepam, quinidine, quinine, racemethorphan, ranitidine, remoxipride, risperidone, salicylic acid, scopolamine, secobarbital, sertraline, sotalol, spironolactone, sulfinpyrazone, sulindac, temazepam, terbutaline, terfenadine, tetracaine, theophylline, thiethyl-perazine, thiopental, thioridazine, thiothixene, timolol, tocainide, tolbutamide, tolmetin, trazodone, triamterene, triazolam, trifluoperazine, triflupromazine, trimeprazine, trimethoprim, trimipramine, verapamil, warfarin, xylometazoline, yohimbine, zopiclone... 

Also analyzed clonidine, diltiazem, metoprolol, nifedipine, prazosin, propranolol, verapamil... 

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