Pp60v-src protein tyrosine kinase

Halistanol sulfate (532) from Halichondria cf. moorei is a tris-sodium sulfate salt, which possesses antimicrobial, hemolytic, and ichthyotoxic activity [444]. It was later isolated from two sponges of the genus Topsentia as the free sterol and found to inhibit pp60v-src protein tyrosine kinase activity [445]. The tris(2-aminoimidazolium) salt of halistanol sulfate (533) was isolated from Topsentia sp. from Japan and is also antimicrobial [446]. 

Melemeleones A and B (320 and 321) possess a 4,9-friedodrimane sesquiterpene array linked to a quinone bearing a taurine and they are structurally related to avarol. Compounds 320 and 321 were isolated from the sponge Dysidea sp. and identified by analysis of their spectroscopic data. Compound 321 showed a moderate inhibitory activity against the pp60v src protein Tyrosine Kinase with an IC50 of 28 pM [236]. 

Govindan, M., Abbas, S. A., and Schmitz, F. J., New cycloartanol sulfates from the alga Tydemania expeditionis inhibitors of the protein tyrosine kinase pp60v src, J. Nat. Prod., 57, 74, 1994. 

Mimnaugh EG, Worland PJ, Whitesell L, et al. 1995. Possible role for serine/threonine phsphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and pp60v-src tyrosine kinase. J Biol Chem 270 28654-28659. 

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