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Potential gradients membrane cells

The powerful biological machinery of energy conversion proceeds via redox reactions in aqueous media that involve electron and proton transfer between molecular entities. - Nature devised concerted sequences of these processes that generate electrochemical potential gradients across cell membranes and thereby enable the storage and the release of electrical energy. [Pg.344]

Ion Channels. The excitable cell maintains an asymmetric distribution across both the plasma membrane, defining the extracellular and intracellular environments, as well as the intracellular membranes which define the cellular organelles. This maintained a symmetric distribution of ions serves two principal objectives. It contributes to the generation and maintenance of a potential gradient and the subsequent generation of electrical currents following appropriate stimulation. Moreover, it permits the ions themselves to serve as cellular messengers to link membrane excitation and cellular... [Pg.279]

The net electrochemical driving force is determined by two factors, the electrical potential difference across the cell membrane and the concentration gradient of the permeant ion across the membrane. Changing either one can change the net driving force. The membrane potential of a cell is defined as the inside potential minus the outside, i.e. the potential difference across the cell membrane. It results from the separation of charge across the cell membrane. [Pg.457]

Recent work has shown that bacteria, in common with chloroplasts and mitochondria, are able, through the membrane-bound electron transport chain aerobically, or the membrane-bound adenosine triphosphate (ATP) anerobically, to maintain a gradient of electrical potential and pH such that the interior of the bacterial cell is negahve and alkaline. This potential gradient and the electrical equivalent of the pH difference (1 pH unit = 58 mV at 37°C) give a potential difference across the membrane of 100-180 mV, with the inside negative. The membrane is impermeable to protons, whose extmsion creates the potential described. [Pg.257]

The ideas of Overton are reflected in the classical solubility-diffusion model for transmembrane transport. In this model [125,126], the cell membrane and other membranes within the cell are considered as homogeneous phases with sharp boundaries. Transport phenomena are described by Fick s first law of diffusion, or, in the case of ion transport and a finite membrane potential, by the Nernst-Planck equation (see Chapter 3 of this volume). The driving force of the flux is the gradient of the (electro)chemical potential across the membrane. In the absence of electric fields, the chemical potential gradient is reduced to a concentration gradient. Since the membrane is assumed to be homogeneous, the... [Pg.87]

Each of their receptors transmits its signal across the plasma membrane by increasing transmembrane conductance of the relevant ion and thereby altering the electrical potential across the membrane. For example, acetylcholine causes the opening of the ion channel in the nicotinic acetylcholine receptor (AChR), which allows Na+ to flow down its concentration gradient into cells, producing a localized excitatory postsynaptic potential—a depolarization. [Pg.41]

The transmembrane potential of cardiac cells is determined by the concentrations of several ions—chiefly sodium (Na+), potassium (K+), calcium (Ca2+), and chloride (Cl-)—on either side of the membrane and the permeability of the membrane to each ion. These water-soluble ions are unable to freely diffuse across the lipid cell membrane in response to their electrical and concentration gradients they require aqueous channels (specific pore-forming proteins) for such diffusion. Thus, ions move across cell membranes in response to their gradients only at specific times during the cardiac cycle when these ion channels are open. The movements of the ions produce currents that form the basis of the cardiac action potential. Individual channels are relatively ion-specific, and the flux of ions through them is... [Pg.272]

Flow of protons back into the bacterial cell, down the electrochemical potential gradient, is mediated by an ATP-synthase resembling the ATP-synthase of the mitochondrial inner membrane (see chapter 14). As in mitochondria, the movement of protons through the F0 base-piece of the enzyme drives the formation of ATP (see fig. 15.13). [Pg.340]

In purple photosynthetic bacteria, electrons return to P870+ from the quinones QA and QB via a cyclic pathway. When QB is reduced with two electrons, it picks up protons from the cytosol and diffuses to the cytochrome bct complex. Here it transfers one electron to an iron-sulfur protein and the other to a 6-type cytochrome and releases protons to the extracellular medium. The electron-transfer steps catalyzed by the cytochrome 6c, complex probably include a Q cycle similar to that catalyzed by complex III of the mitochondrial respiratory chain (see fig. 14.11). The c-type cytochrome that is reduced by the iron-sulfur protein in the cytochrome be, complex diffuses to the reaction center, where it either reduces P870+ directly or provides an electron to a bound cytochrome that reacts with P870+. In the Q cycle, four protons probably are pumped out of the cell for every two electrons that return to P870. This proton translocation creates an electrochemical potential gradient across the membrane. Protons move back into the cell through an ATP-synthase, driving the formation of ATP. [Pg.340]

For each ATP that it splits, the Na+-K+ pump moves three Na+ ions out of the cell and brings in two K+ ions. This means that the pump is intrinsically electrogenic It creates an electric potential gradient across the membrane... [Pg.404]

Action potentials are waves of depolarization and repolarization of the plasma membrane. In a resting nerve cell, the electric potential gradient (At//) across the plasma membrane is about —70 mV, inside negative. This potential difference is generated mainly by the unequal rates of diffusion of K+ and Na+ ions down concentration gradients maintained by the Na+-K+ ATPase. [Pg.612]

The term electromembrane process is used to describe an entire family of processes that can be quite different in their basic concept and their application. However, they are all based on the same principle, which is the coupling of mass transport with an electrical current through an ion permselective membrane. Electromembrane processes can conveniently be divided into three types (1) Electromembrane separation processes that are used to remove ionic components such as salts or acids and bases from electrolyte solutions due to an externally applied electrical potential gradient. (2) Electromembrane synthesis processes that are used to produce certain compounds such as NaOH, and Cl2 from NaCL due to an externally applied electrical potential and an electrochemical electrode reaction. (3) Eletectromembrane energy conversion processes that are to convert chemical into electrical energy, as in the H2/02 fuel cell. [Pg.83]

Maintenance of unequal concentrations of ions across membranes is a fundamental property of living cells. In most cells, the concentration of K+ inside the cells is about 30 times that in the extracellular fluids, while sodium ions are present in much higher concentration outside the cells than inside. These concentration gradients are maintained by the Na+-K+-ATPase by means of the expenditure of cellular energy. Since the plasma membrane is more permeable to K+ than to other ions, a K+ diffusion potential maintains membrane potentials which are usually in the range of -30 to -90 mV. H+ ions do not behave in a manner different from that of other ions. If passively distributed across the plasma membrane, then the equilibrium intracellular H+ concentration can be calculated from the Nernst equation via... [Pg.152]


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See also in sourсe #XX -- [ Pg.319 ]




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