Potassium supplements, interaction

The hypotensive effects of most antihypertensive dru are increased when administered with diuretics and other antihypertensives. Many dnigp can interact with the antihypertensive drugs and decrease their effectiveness (eg, antidepressants, monoamine oxidase inhibitors, antihistamines, and sympathomimetic bronchodilators). When the ACE inhibitors are administered with the NSAIDs, their antihypertensive effect may be decreased. Absorption of the ACE inhibitors may be decreased when administered with the antacids. Administration of potassium-sparing diuretics or potassium supplements concurrently with the ACE inhibitors may cause hyperkalemia. When the angiotensin II receptor agonists are administered with... 

Important drug interactions include those with potassium supplements or potassium-sparing diuretics, which can result in hyperkalemia. Nonsteroidal anti-inflammatory drugs may impair the hypotensive effects of ACE inhibitors by blocking bradykinin-mediated vasodilation, which is at least in part, prostaglandin mediated. 

Clinically important, potentially hazardous interactions with allopurinol, amiloride, cimetidine, corticosteroids, cyclosporine, insulin, lithium, potassium sparing diuretics, potassium supplements, procainamide, spironolactone, triamterene... 

The documentation of this interaction appears to be limited, but it is well established. In practice, a clinically relevant rise in potassium levels usually occurs only if other factors are also present, the most important of which is impaired renal function. In general, because ACE inhibitors have potassium-sparing effects, potassium supplements should not routinely be given concurrently. If a supplement is ne ed, serum potassium should be closely monitored. This is especially important where other possible contributory risk factors are known to be present. 

The concurrent use of spironolactone or triamterene and potassium suppiements can resuit in severe and even life-threatening hyperkalaemia. Amiloride and eplerenone are expected to interact similarly. Potassium-containing salt substitutes can be as hazardous as potassium supplements. 

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