Potassium-sparing diuretics antagonists Sodium

Ascites. Patients with cirrhosis, especially fiver cirrhosis, very often develop ascites, ie, accumulation of fluid in the peritoneal cavity. This is the final event resulting from the hemodynamic disturbances in the systemic and splanchnic circulations that lead to sodium and water retention. When therapy with a low sodium diet fails, the dmg of choice for the treatment of ascites is furosemide, a high ceiling (loop) diuretic, or spironolactone, an aldosterone receptor antagonist/potassium-sparing diuretic. 

Amyloride is also a potassium sparing diuretic that exhibits moderate activity. It is not an antagonist of aldosterone. It inhibits reabsorption of sodium ions and reduces excretion of... 

POTASSIUM-SPARING DIURETICS SULPHONYLUREAS -CHLORPROPAMIDE Risk of hyponatraemia when chlorpropamide is given to a patient taking both potassiumsparing diuretics/aldosterone antagonists and thiazides Additive effect chlorpropamide enhances ADH secretion Monitor serum sodium regularly... 

Potassium-sparing diuretic A diuretic that reduces the exchange of potassium for sodium in the collecting tubule a drug that increases sodium and reduces potassium excretion. Example aldosterone antagonist... 

Excessively low sodium levels have been seen in a few patients taking hydrochlorothiazide with amiloride or triamterene when they were given trimethoprim or co-trimoxazole. Trimethoprim may cause hyperkalaemia and this may be additive with potassium-sparing diuretics, including the aldosterone antagonists. 

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