Potassium, liver content

Moen, J., Claeson, K., Pienaar, H., Lindell, S., Ploeg, R.J., McAnulty, J.F., Vreugdenhil, P., Southard, J.H. and Belzer, F.O. (1989). Preservation of dog liver, kidney, and pancreas using the Belzer-UW solution with a high-sodium and low potassium content. Transplantation 47, 940-945. 

The inhibition of amino-acid transport has been regarded as the main toxic effect of mercury compounds [82], The biochemical mechanism underlying the inhibition is unclear. In unfertilized sea-urchin eggs an interaction with the amino-acid carrier was found, whereas in fertilized eggs inhibition of amino-acid transport was indirect and might result from an elevation of the Na + content of the egg caused by the inhibition of the Na+ pump [83]. The action on the diffusional process could be mediated by an effect on membrane phospholipids or on membrane proteins, or by interaction with Ca2+ which stabilizes membrane structure. Mercuric chloride in skate liver cells inhibited amino acid transport, decreased Na + /K + -ATPase (adenosinetriphosphatase) activity, impaired volume regulatory mechanisms and increased the permeability of the plasma membrane to potassium [84]. It has been suggested that... 

Exposure-dependent decrease in respiration rate 53 and content of sodium, potassium, and calcium in gill, brain, muscle and liver. At 48 h, whole animal respiration rate decreased 51%, tissue Na content by 28-40%, tissue K content by 28-34°/ o, and tissue Ca content by 19-36%... 

Price et al. (1996) compared the toxicity of 0.5, 1 and 2 mmol/L coumarin in 24 h cultured precision-cut male Sprague-Dawley rat, Dunkin-Hartley guinea-pig, cyno-molgus monkey and human liver slices. Coumarin toxicity, based on liver protein synthesis and potassium content, was concentration-dependent in rat and guinea-pig liver, whereas monkey and human liver were relatively resistant. 

The chromium content in major organs of mice receiving drinking water that provided doses of 4.8, 6.1, or 12.3 mg chromium(III)/kg/day as chromium trichloride or 4.4, 5.0, or 14.2 mg chromium(VI)/kg/day as potassium dichromate was determined after 1 year of exposure. Chromium was detected only in the liver in the chromium(III)-treated mice. Mice treated with chromium(VI) compounds had accumulation in all organs, with the highest levels reported in liver and spleen. Liver accumulation of chromium was... 

Tab. 1.3-8 Potassium content of ribs, liver and kidneys of humans as a function of age and gender (g K kg DM n = 188, 191, 202, respectively)...

Sulphurated potash (Liver of Sulphur) consists of a mixture of potassium polysulphides, thiosulphate and other salts. It is standardised on its total sulphur content determined by the alkaline bromine oxidation method given above under Sulphur. 

We have studied the effect of ozone [191] on POL of rabbit brain and liver. In this connection the rabbits were exposed to ozone action in a special chamber for 2, 3, 10 and 15 h. The ozone concentration in the gas phase was varied in the range 50-250 ppm. We have found a substantial enhancement of the content of endogenous POL fluorescence products (FP) and TBA-reacting products (TBA-rp) after 2 h exposure to 250 ppm ozone concentration. However, after 4 h exposure to the same ozone concentration the rabbits die. When the concentration of exposed ozone was 50 ppm the increase in FP content in the rabbits brain is increased by about 1.8 times after 10 h, and in the liver - by about fold 2 compared with that of the control test. The level of TBA-rp was 3.1 and 3-fold higher, respectively. It has been observed that the amount of FP in the brain between the 10th and 15th h does not change, but the FP content in the liver microsomes rises 2.6 times and that of TBA-rp - 3. 6 fold. A series of test animals, which were preliminary injected with 56 mg/kg potassium salt of DL-a-tocopherol 10 h before the test, were also studied under the same conditions. The results from FP determination after 10 and 15 h of exposure reveal that their amount in the brain has increased by 1.09 and 1.3 times, respectively and in the liver microsomes -1.5 and 1.9 fold. Simultaneously there is no marked difference in the DL-a-tocopherol content before and after exposure of the test animals as demonstrated by the HPLC data. These facts indicate that the brain is either more stable or more pro-... 

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