Potassium channels mammalian

FIGURE 2 Examples of the variety of structures obtained in natural product screens. I, zaragozic acid A, is an inhibitor of mammalian and fungal sterol synthesis, obtained from fungi (48) II, L-696,474, is an inhibitor of the HIV protease, obtained from fungi (51) III, dehydrosoyasaponin I, is an agonist of the calcium-activated potassium channel, obtained from a medicinal plant (58) IV, tetrandrine, is an inhibitor of L-type calcium channels, obtained from a plant (78). 

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Guo J, Ikeda SR (2004) Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB 1 cannabinoid receptors heterologously expressed in mammalian neurons. Mol Pharmacol 65 665-674... 

Venom of Israeli scorpion (Leiurus quinquestria-tus). Protein toxin MW 7000. Blocks calcium-activated potassium channels in mammalian skeletal muscle. 

Prolongation of QT interval may be predicted in vitro by patch clamp electrophysiology in mammalian cells transfected with the human ether-d-go-go-related gene (hERG), a subunit of the (cardiac rapidly activating delayed rectifier potassium channel), or by measuring a compound s abihty... 

Table 3 Types of mammalian cardiac voltage- and ligand-gated potassium channels...

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