Antacids potassium bicarbonate

Potassium bicarbonate is used in baking powder and effervescent salts. In medicine, the salt is a gastric antacid and an electrolyte replenisher. It also is dry powder in fire extinguishers. 

Therapeutically, potassium bicarbonate is used as an alternative to sodium bicarbonate in the treatment of certain types of metabolic acidosis. It is also used as an antacid to neutralize acid secretions in the gastrointestinal tract and as a potassium supplement. 

Compounds used as antacids are sodium bicarbonate potassium bicarbonate calcium carbonate aluminium hydroxide magnesium salts... 

One of the most familiar applications of potassium bicarbonate is as an antacid to treat the symptoms of upset stomach. The compound reacts with stomach acid-hydrochloric acid ... 

Related in vitro studies by the same authors using segments of rat intestine found that the absorption of chloroquine was decreased as follows magnesium trisilicate 31.3%, kaolin 46.5%, calcium carbonate 52%, and gerdiga 36.1%. Gerdiga is a clay containing hydrated silicates with sodium and potassium carbonates and bicarbonates. It is used as an antacid and is similar to attapulgite. ... 

Methenamine and methenamine mandelate are only effective as urinary antisepties if the pH is about 5.5 or lower, when formaldehyde is released. This is normally achieved by giving urinary acidifiers such as ammonium chloride, ascorbic acid, or sodium acid phosphate. In the case of methenamine hippurate, the acidification of the urine is achieved by the presence of hippuric acid. The concurrent use of substances that raise the urinary pH such as acetazolamide, sodium bicarbonate, potassium or sodium citrate is clearly contraindicated. Potassium citrate mixture BPC has been shown to raise the pH by more than 1 at normal therapeutic doses, thereby making the urine sufficiently alkaline to interfere with the activation of methenamine to formaldehyde. Some antacids (containing magnesium, aluminium or calcium as well as sodium bicarbonate mentioned above) can also cause a significant rise in the pH of the urine. ... 

Treatment has also presented problems. One child was originally given allopurinol with bicarbonate when the stones were first reported to be uric acid (4), with no diminution in stone formation. The child has since been stone free for more than five years on allopurinol alone (10 mg/kg) without alkali (4). Another child was probably given antacid tablets prior to her presentation at the age of 19 months (5). One of the most recent cases (10) was treated with potassium citrate for a month presuming a uric acid stone, following the identification of a radiolucent stone by IVP and iric acid crystals in the urine. IVP one month later demonstrated an increase in the filling defect (10). Allopurinol without alkali (10 or 5 mg/kg, dependent on renal function) has elimanted 2,8-DHA from the urine and with it any further stone formation in affected subjects to date (6). 

Table 14.2 lists some common bases. Sodium hydroxide and potassium hydroxide are found in most chemistry laboratories. They are also used in processing petroleum and cotton and in soap and plastic manufacturing. Sodium hydroxide is the active ingredient in products such as Drano that work to unclog drains. Sodium bicarbonate can be foimd in most homes as baking soda and is also an active ingredient in many antacids. When taken as an antacid, sodium bicarbonate neutralizes stomach acid (see Section 14.5), relieving heartburn and sour stomach. 

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