Posttraumatic stress disorder sertraline

Posttraumatic stress disorder (PTSD) Paroxetine (immediate-release except Pexeva), sertraline. 

Boyer W (1995) Serotonin uptake inhibitors are superior to imipramine and alprazolam in alleviating panic attacks a meta-analysis. Int Clin Psychopharmacol 10 45-49 Brady K, Pearlstein T, Asnis GM, Baker D, Rothbaum B, Sikes CR, Farfel GM (2000) Efficacy and safety of sertraline treatment of posttraumatic stress disorder a randomized controlled trial. JAMA 283 1837-1844... 

Frank JB, Kosten TR, Giller EL Jr, Dan E (1988) A randomized clinical trial of phenelzine and imipramine for posttraumatic stress disorder. Am J Psychiatry 145 1289-1291 Goddard AW, Brouette T, Almai A, Jetty P, Woods SW, Charney D (2001) Early coadministration of clonazepam with sertraline for panic disorder. Arch Gen Psychiatry 58 681-686 Goodnick PJ, Goldstein BJ (1998) SSRIs in affective disorders. I. Basic pharmacology. J Psychopharmacol 12(Suppl B) S5-S20... 

Brady KT, Sonne SC, Roberts JM. Sertraline treatment of comorbid posttraumatic stress disorder and alcohol dependence. J Clin Psychiatry 1995 56 502-505. 

Sertraline hydrochloride is used in the management of depression, obsessive-compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder. 

PTSD compares with depression in the level of disability it imposes on patients with the disorder. Individuals fail to realize their potentials for career development, marriage, and education. Decreased productivity leads to a financial loss of more than 3 billion per year. This figure does not include economic loss associated with the failure of patients with PTSD to achieve their educational or career goals. Women in a health care maintenance organization with high scores on the Posttraumatic Stress Disorder Checklist had more than twice the adjusted total annual median cost ( 1,283) of care (i.e., outpatient, specialty care, primary care, pharmacy and mental health care costs) than those with a low score ( 609). Treatment with effective pharmacotherapy can improve the QOL of these patients. Sertraline and fluoxetine improved measures of social and occupational functioning as well as the perception of improved QOL in patients with PTSD. - ... 

Brady K, Pearlstein T, Asnis GM, et al. Efficacy and safety of sertraline treatment of posttraumatic stress disorder A randomized controlled trial. JAMA 2000 283 1837-1844. 

Davidson JRT, Pearlstein T, Londborg P, et al. Efficacy of sertraline in preventing relapse of posttraumatic stress disorder Results of a 28-week double-blind, placebo-controlled study. Am J Psychiatry 2001 158 1974-1981. 

Smajkic A, Weine S, Djueric-Bijedic Z, et al. Sertraline, paroxetine, and venlafaxine in refugee posttraumatic stress disorder with depression symptoms. J Traumatic Stress 2001 14 445-452. 

Selective serotonin reuptake inhibitors (SSRIs) A relatively new group of medicines that have been used successfully to treat emotional and behavioral problems such as depression, panic disorder, obsessive-compulsive disorder ((XID), bulimia, and posttraumatic stress disorder in adults. These medications are now being used to treat the same types of behavior in children. Some examples of SSRIs include Prozac (fluoxetine), Zoloft (sertraline), Luvox (fluvoxamine), and Paxil (paroxetine). 

HT transporter Inhibitor Fluoxetine, sertraline Depression panic, obsessive-compulsive, and posttraumatic stress disorders social phobia... 

Zohar j, Amital D, Miodownik C et al. Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder, j Clin Psychopharmacol 2002 22 190-195. 

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