Postischemic oxygen radical production

Postischemic oxygen radical production is also accentuated by hyperthermia. Microdialysis studies sampling the brain s extracellular fluid for a signal of hydroxyl radical production have revealed two- to threefold elevations after normothermic global ischemia, but four- to... 

Agardh, C.D., Zhang, H., Smith, M.-L. and Siesjo, B.K. (1991) Free radical production and ischemic brain damage influence of postischemic oxygen tension. Int. J. Dev. Neu-rosci. 9 127-138. 

Kunz A, Anrather J, Zhou P, Orio M, ladecola C (2007) Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species. J Cereb Blood Flow Metab 27 545-551 Lagrange P, Romero lA, Minn A, Revest PA (1999) Transendothelial permeabihty changes induced by free radicals in an in vitro model of the blood-brain barrier. Free Radic Biol Med 27 667-672 Lai CH, Kuo KH (2005) The critictil component to establish in vitro BBB model pericyte. Brain Res Brain Res Rev 50 258-265... 

The cardioprotective effect of melatonin is demonstrated in several studies in in vivo and ex vivo experimental rat models or cardiomyocytes, as reviewed by Reiter.30 Melatonin administration in perfused rat hearts subjected to ischemia and reperfusion increased postischemic recovery of function, reduced the duration of ventricular tachycardia and ventricular fibrillation and this was associated with decreased lipid peroxidation products and OH radical formation, indicating an antioxidant effect of melatonin.31 Furthermore, in pinealectomized rats, occlusion of the left coronary artery followed by reperfusion resulted in significant increase in infarct size than in intact animals.32 Melatonin acts as scavenger of oxygen or nitrogen based reactants, stimulates antioxidant enzymes, stabilizes cellular membrane, increases the efficiency of oxidative phosphorylation, reduces leukocyte recruitment and adhesion molecule expression and reduces homocysteine induced damage (reviewed by Duncker33). 

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