Possible pathogenic mechanisms

Rathbone, B.J. and Heatley, R.V. (1992). Possible pathogenic mechanisms in Helicobacter pylori infection. In Helicobacter pylori and Gastroduodenal Disease (eds. B.J. Rathbone and R.V. Heatley) pp. 217-223. Blackwell Scientific Pubhcations, Oxford. 

O. Fejerskov, A. Thylstrup, M.J. Larsen, Clinical and structural features and possible pathogenic mechanisms of dental fluorosis, Scand. J. Dent. Res. 85 (1977) 510-534. [47] T. Ishii, G. Suckling, The severity of dental fluorosis in children exposed to water with a high fluoride content for various periods of time, J. Dent. Res. 70 (1991) 952-956. B.K.B. Berkovitz, G.R. Holland, B.J. Moxham, Oral Anatomy, Histology and Embryology, 3rd edition, Mosby, Edinburgh, 2002. 

Armstrong RA, Winsper SJ, Blair JA. 1996. Aluminium and Alzheimer s disease Review of possible pathogenic mechanisms. Dementia 7 1-9. 

Miyauchi H, Hosokawa H, Akaeda T, Iba H, Asada Y. T-cell subsets in drug-induced toxic epidermal necrolysis. Possible pathogenic mechanism induced by CD8-positive T cells. Arch Dermatol 1991 127(6) 851-5. 

Raychaudhuri, S.P. et al. (1999) Upregulation of RANTES in psoriatic keratinocytes a possible pathogenic mechanism for psoriasis. Acta Dermato-Venereologica, 79, 9-11. 

Williams, H.E. and Smith, L.H. (1971), Hyperoxaluria in L-glyceric aciduria Possible pathogenic mechanism. Science, 171,390. 

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown aetiology with some autoimmune features. Current thinking favours the hypothesis that interplay between genetic factors, sex hormones, and possibly an infectious agent or another immune activating agent initiates an autoimmune pathogenic mechanism that culminates in a disease with inflammatory and destructive features. 

In Figure 1.1, a possible structure for such a consortium is shown. First, general considerations lead to a hypothesis which comprises an approach for understanding pathogenic mechanisms of a specific disease. Based on this hypothesis, the appropriate tissue as well as the suitable model organism must be defined, and providers of the relevant samples found. For networking reasons, integration... 

However, it is not always clear with regard to the respective cause how the pathogenic mechanism triggers cholestasis. It cannot be adequately explained why one particular cause acts as a cholestatic factor in the individual case or why the same factor possibly has no effect at all. It would appear that genetic disposition is of decisive importance. Influences of everyday life (xenobiotics, drugs, alcohol, etc.), differing performances of biotransforma-... 

Surprisingly, alcoholic fatty infiltration of the liver and alcoholic hepatitis often display ascites as well, mostly only discernible when applying ultrasonic methods of examination. This might suggest that certain pathogenic mechanisms in the formation of ascites (such as increase in portal pressure, structural sinus changes, and stimulation of biochemical or sympathoadrenergic factors) are favoured or become more intense as a result of alcohol (and possibly also its chemical additives). Ascites can also occur in severe acute viral hepatitis, in which case the course of disease deteriorates considerably. (28,46,64)... 

Regardless of the pathogenic mechanism associated with pulmonary fibrosis, therapy should be directed toward attenuating the inflammatory and immune process (alveolitis) associated with the disease because therapy is much less effective once pulmonary fibrosis has developed. If possible, the agent inciting the alveolitis should be identified and removed, and steroid therapy initiated. 

With the recent publication from WHO and IDF on definition and diagnosis of diabetes melhtus and intermediate hyperglycaemia [4], a natural question could be - have we now reached the end of the road Unfortunately, the only possible answer is a no. Science is progressing, and as part of this, our understanding of the underlying aetiology and pathogenic mechanisms behind abnormalities in... 

Note that we use AAM instead of the term sarco-penia. "Sarcopenia" sounds like a definitive diagnosis but it is not. It is often erroneously interpreted as designating a singular pathogenesis. Sarcopenia simply refers, imprecisely, to muscle atrophy in aged animals it does not indicate or imply any pathogenic mechanism, of which there are a number of possibilities. AAM is usually manifest as type-2 fiber atrophy. A further critique of "sarcopenia" is presented below. 

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