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Positron radiopharmaceuticals

Gatley SJ (1996) Positron radiopharmaceutical agents and their chemistry. In Henkin RE, Boles MA, DUlehay GL, Halama JR, Karesh SM, Wagner RH, Zimmer AM (eds) Nuclear medicine. Mosby, St Louis, pp 429-444... [Pg.441]

In 2003 LJngstrOm and Samuelsson described the synthesis of a radiopharmaceutical for PET (positron emission tomography) using a microwave-assisted Stille reaction [25]. l-(2 -Deoxy-2 -fluoro- 6-D-arabinofuranosyl)-... [Pg.159]

Metals continue to play an important role in radiopharmaceuticals for diagnostic and therapeutic applications in nuclear medicine. Radiopharmaceuticals are drugs that contain a radionuclide and are used for imaging if the radionuclide is a photon emitter (gamma (7) or positron (/3+)) or for... [Pg.883]

A specialized application of microwave-assisted organic synthesis involves the preparation of radiopharmaceuticals labeled with short-lived radionuclides, particularly for use in positron emission tomography [70-72]. This represented an excellent application of microwave technology, where the products must be prepared quickly and in high radiochemical yield, on a small scale. [Pg.56]

Sharma V, Piwnica-Worms D (2005) Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon-Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals. 252 155-178 Shinkai S, see Ishi-i T (2005) 258 119-160... [Pg.205]

Nuclear medicine is used chiefly in medical diagnosis. A radiopharmaceutical—a relatively harmless compound with a low dose of radiation— is swallowed or injected into the patient and tracked through the bloodstream by instruments such as a PET (positron emission tomography) camera. The nuclear physician can use the results to create a... [Pg.129]

The apphcations described here illustrate the wide range of uses for robotic systems. This chapter is not intended to he exhaustive there are many other examples of successful applications, some of which are referenced below. For instance, Brodach et al. [34] have described the use of a single robot to automate the production of several positron-emitting radiopharmaceuticals and TTiompson et al. [3S] have reported on a robotic sampler in operation in a radiochemical laboratory. Both of these apphcations have safety imphcations. CHnical apphcations are also important, and Castellani et al. [36] have described the use of robotic sample preparation for the immunochemical determination of cardiac isoenzymes. Lochmuller et al. [37], on the other hand, have used a robotic system to study reaction kinetics of esterification. [Pg.196]

The most useful and important positron emitting radiopharmaceuticals, 2-deoxy-2-[ F]fluoro-D-deoxyglucose [ F]FDG, is prepared in a two-step... [Pg.241]

Stocklin G, Pike VW (eds) (1993) Radiopharmaceuticals for positron emission tomography. Cox PH (series ed) Development in nuclear medicine, vol 24, Klimder Academic Publishers, Dordrecht... [Pg.251]

The next two chapters are dedicated to radiopharmaceutical contrast agents starting with a detailed description of the chemistry of p -emitting compounds based on fluorine-18. Particular emphasis is laid on the different radiolabeled precursors and their suitability for the rapid synthesis of compounds useful for positron emission tomography. [Pg.299]

Design of radiotracers and radiopharmaceuticals labelled with a short-lived positron emitter The case of fluorine-18... [Pg.3]

G. Stocklin, V.W. Pike, Radiopharmaceuticals for Positron Emission Tomography, Kluwer Academic Publishers, Dordrecht - Boston - London, (1993). [Pg.50]

P.H. Elsinga, Radiopharmaceutical chemistry for positron emission tomography. Methods 27 (2002) 208-217. [Pg.52]

The main feature of the short-lived positron-emitting isotope F is the relative long half-life of 110 min. The ultrashort-lived isotopes C, N, and O have half-lives of 2-20 min, and they must subsequently be produced in the vicinity of the PET scanner(s). Radiopharmaceuticals labeled with F, on the contrary, can be shipped to distant satellite PET centers that are notequippedwith a cyclotron. Several commercial companies are today producing 2-[ F]fluoro-2-deoxy-D-glucose... [Pg.69]

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See also in sourсe #XX -- [ Pg.140 ]



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