Porphyria experimental

B.C. Shanley, V.A. Percy, A.C. Neethling (1976). Neurochemistry of acute porphyria. Experimental studies on delta-aminolaevulinic acid and porphobilinogen. In M. Doss (Ed.), Porphyrins in Human Diseases (pp. 156-162). Karger, Basel. 

Rimington GE, Ziegler G. 1963. Experimental porphyria in rats induced by chlorinated benzenes. Biochem Pharmacol 12 1387-1397. 

Toxicology. Hexachlorobenzene (HCB) causes porphyria, enlarged liver and thyroid, and neurological symptoms it is a developmental toxin, and in experimental animals it is carcinogenic. 

Goldstein JA, Hickman P, Jue DL. 1974. Experimental hepatic porphyria induced by polychlorinated biphenyls. Toxicol Appl Pharmacol 27 437-448. 

Tephly, T.R., A.H. Gibbs, G. Ingall, and F. De Matteis (1980). Studies on the mechanism of experimental porphyria and ferrochelatase inhibition produced by 3,5-diethoxycarbonyl-l,4-dihy-drocollidine. Int. J. Biochem. 12, 993-998. 

Stejskal, R., M. Itabashi, J. Stanek, and Z. Hruban (1975). Experimental porphyria induced by 3-[2-(2,4,6-trimethylphenyl)-thioethyl]-4-methyl-sydnone. Virchows Arch. 18, 83-100. 

Experimental exposure of animals to these xcnobiotics elicits a number of effects, including lipid mobilization, porphyria, hypothyroidism, an increased liver-to-body weight ratio, testicular atrophy, a progressive weight loss with hypophagia, and depletion of adipose tissues (Bagchi... 

In a clinical study it has been emphasized not only how the decreased food intake in for example slimming, induced attacks in 11% of patients with acute intermittent porphyria, but they also demonstrated how the urinary output of porphyrin precursors varied inversely with the amount of carbohydrate and protein in the diet [94]. The inhibitory effect of carbohydrate feeding on ALA-synthetase induction has also been demonstrated experimentally [95, 96, 97]. 

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