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Polysialic acids functions

The neuA (ORF 25) and neuB (ORF 24) gene products were functionally characterized by complementation of E. coli K1 mutants EV5 and EV24 that are defective in K1 polysialic acid capsule biosynthesis. The EV5 mutant was complemented to wild-type capsule production by introduction of neuA, and the EV24 mutation complemented by the neuB gene. [Pg.384]

The configurations of the glycosidic bond in natural polycondensed polymers of sialic acid are a-(2—>8) and a-(2- 9). Exceptionally, in the polysialic acid of starfish, the interglycosidic bond involves the primary alcohol function of the... [Pg.279]

Miihlenhoff, M., Eckhardt, M., Gerardy-Schahn, R. (1998). Polysialic acid three-dimensional structure, biosynthesis, and function. Curr. Opin. Struct. Biol., 8, 558-564. [Pg.218]

Apart from their intrinsic role in tissue functioning, the carbohydrate units participate in other types of biological interactions such as the pathogenesis of microbial diseases. As indicated above for polysialic acid some pathogens may mimic host tissue oligosaccharide structures in order to escape immunological defence. In addition, microbes... [Pg.65]

In reproductive biology, sialic acid polymers are receiving more and more attention. Polysialic acid with a(2-8)-linkages was found to be expressed on mouse embryos before and after implantation and the neuronal cell adhesion molecule (NCAM), which bears a polysialic acid chain, seems to be involved in cellular interactions in the early mammalian embryo [101,1076]. A similar function is attributed to polysialic acid observed during a short period of the larval stage of Drosophila melanogaster [1077]. It has to be noted that this is the first report on the occurrence of sialic acid in insects. [Pg.369]

Sato C, Kitajima K (2011) New functions of polysialic acid and its relationship to schizophrenia. Trends Glycosci Glycotechnol 23 221-238... [Pg.99]

Sato C (2013) Polysialic acid. In Tiralongo J, Martinez-Duncker I (eds) Sialobiology structure, biosynthesis, and function, Bentham Science, pp 33-75. http //www.eurekaselect. com/107046/volume/l... [Pg.99]

Isomura R, Kitajima K, Sato C (2011) Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia. J Biol Chem 286 21535-21545... [Pg.99]

Muhlenhoff, M. Oltmann-Norden, I. Weinhold, B. Hildebrandt, H. Gerardy-Schahn, R. Brain development needs sugar The role of polysialic acid in controlling NCAM functions. Biological Chemistry 2009,390, 567-574. [Pg.307]

Troy, F. A., Cho, J.-W., and Ye, J., 1993, Polysialic acid capsule synthesis and chain translocation in neuroinvasive E. coli Activated intermediates and a possible functional role for unde-caprenol, in Polysialic Acid From Microbes to Man (J. Roth, U. Rutishauser, and F. A. Troy, eds.), Birkhauser Verlag, Basel, pp. 93-111. [Pg.142]

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See also in sourсe #XX -- [ Pg.97 , Pg.106 ]



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