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Polysaccharide sodium periodate

The oxidative cleavage of v/c-diols to give two carbonyl functions (Eq. 5.3) by periodates was first observed by Malaprade and has since been widely applied to the carbohydrate area.50 Since both the reagent sodium periodate and the carbohydrate substrate are water soluble, the reaction is usually carried out in aqueous media.51 The reaction has been applied to polysaccharides such as starch.52 The periodate oxidations of sodium alginate in water as well as a dispersion in 1 1 ethanol-water mixture have been compared.53 Because sodium alginate forms a highly viscous solution, the oxidation was observed to be more extensive in ethanol-water. [Pg.153]

Oxidation of polysaccharides using 10 mM or greater concentrations of sodium periodate at room temperature results in the cleavage of adjacent hydroxyl-containing carbon-carbon bonds on other sugars besides just sialic acid residues (Lotan et al., 1975). High concentrations... [Pg.130]

The carbonyl-reactive group on these crosslinkers is a hydrazide that can form hydrazone bonds with aldehyde residues. To utilize this functional group with carbohydrate-containing molecules, the sugars first must be mildly oxidized to contain aldehyde groups by treatment with sodium periodate. Oxidation with this compound will cleave adjacent carbon-carbon bonds which possess hydroxyl groups, as are abundant in polysaccharide molecules (Chapter 1, Sections 2 and 4.4). [Pg.298]

Figure 10.3 Antibody molecules oxidized with sodium periodate to create aldehyde groups on their polysaccharide chains can be modified with PDPH to produce thiols after reduction of the pyridyl disulfide. Direct labeling of the sulfhydryls with "Tc produces a radioactive complex. Figure 10.3 Antibody molecules oxidized with sodium periodate to create aldehyde groups on their polysaccharide chains can be modified with PDPH to produce thiols after reduction of the pyridyl disulfide. Direct labeling of the sulfhydryls with "Tc produces a radioactive complex.
Molecules containing polysaccharide chains may be oxidized to possess reactive aldehyde residues by treatment with sodium periodate. Any adjacent carbon atoms containing hydroxyl groups will be affected, cleaving the carbon-carbon bond and transforming the hydroxyls into... [Pg.966]

BODIPY 530/550 C3 hydrazide is 4,4-difluoro-5,7-diphenyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl hydrazide, a derivative of the basic BODIPY structure, which contains two phenyl rings off the No. 5 and 7 carbon atoms and a propionic acid hydrazide group on the No. 3 carbon atom (Molecular Probes). The hydrazide functional group reacts with aldehyde- or ketone-containing molecules to form hydrazone linkages (Fig. 229). The compound may be used to label glycoproteins or other carbohydrate-containing molecules after oxidation of their polysaccharide portions with sodium periodate to yield aldehyde residues. [Pg.366]

Periodate oxidation. Aldehyde groups can be easily introduced in most polysaccharides by reaction with sodium periodate. Vicinal diol structures give rise to dialdehydes. For dextran (I) having three adjacent hydroxyl groups in each non-branched anhydro glucopyranoside repeat unit the oxidation is a two step reaction ... [Pg.189]


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See also in sourсe #XX -- [ Pg.123 , Pg.130 , Pg.800 ]

See also in sourсe #XX -- [ Pg.472 ]

See also in sourсe #XX -- [ Pg.472 ]




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