Polypodium vulgare Osladin

Osladin, a steroidal saponin, was isolated as a sweet principle of the fem Polypodium vulgare L. (Polypodiaceae). Later, Nishizawa and Yamada.36 reinvestigated the structure of osladin and revised the stereochemistry at C-22, C-25, and C-26. Although osladin has been reported to be 3000 times sweeter than sucrose, this value was also... 

Osladin Polypodium vulgare (European fern) Sweet (500X >sucrose)... 

The steroidal saponin osladin (58) was isolated as a sweet principle from the fern Polypodium vulgare L. (Polypodiaceae) nearly 40 years ago [20,28]. However, the original structure proposed was later revised because the synthetic compound produced was not sweet at all [87]. The correct structure of osladin (58) was characterized by single crystal X-ray... 

Osladin (62) is a steroidal glycoside that is about 500-times sweeter than sucrose. It was isolated by the Czech chemists Jizba and Herout in 1967 [112] from the rhizomes of European fern Polypodium vulgare known for its very sweet taste. Its structure has been recently revised [113] by total synthesis. During the synthesis it was shown that minute changes in the structure result in total loss of the sweet taste. Thus, this is a t5 ical glycoside whose overall structure - including the glycosidic part - is crucial for the respective activity. 

Another sweet-tasting saponin, osladin (17), occurs at rather low concentrations (about 0.03%) in the roots of the fern Polypodium vulgare (Hodge and Inglett, 1974). Similar steroidal glycosides have been isolated from the rhizomes of Polypodium glycyrrhiza (Kim et al., 1988 Kim and Kinghom, 1989). The major intensely sweet compound of that plant is polypodoside A, a 26-0-a-L-rhamnopyranosyl-pol-... 

Osladin (11-36) is a steroidal saponin occurring in the rhizomes of the common polypody fern (Polypodium vulgare, Polypodi-aceae). Sugar components are a-L-rhamnose and disaccharide a-L-Rhap-(l — 2)-P-d-G1(J) (fl-neohesperidose). Osladin has not find applications due to toxicological reasons. 

Osladin, a sterol bisglycoside, is found in the fern Polypodium vulgare [21]. It has a 2-0-a-L-rhamnopyranosyl-P-D-glucopyranosyl (neohesperidosyl) group at one end and an a-L-rhamnopyranosyl group at the other end (see Fig. 5.6C). It has been reported to be 3,000 times sweeter than sucrose. 

JiZBA, J., L. DolejS, V. Herout, and F. Sorm The Structure of Osladin - The Sweet Principle of the Rhizomes of Polypodium vulgare L. Tetrahedron Letters 1971, 1329. 

---