Polymyxin aerosolized

Note Bacitracin is supplied in many forms and vehicles Intramuscular topical, ophthalmic, otic, aerosols, for irrigations. Many Bacitracin ointments are combinations with Neomycin and Polymyxin B. 

Antimicrobial and antiendotoxin cationic peptide, CM3, incorporated into liposomes was suggested for the aerosol delivery, and corresponding models describing its potential distribution in lungs of patients with different breathing patterns have been developed.Liposomes with calcitonin have been developed for intranasal delivery. Liposomal forms of the peptide antibiotic, polymyxin B, showed certain promise in different models.355-357... 

Bronchospasm frequently complicates aerosolized polymyxin therapy as a result of mast cell degranulation and histamine release as such, a bronchial challenge is recommended before initiating therapy. Tobramycin may offer an advantage over gentamicin when used in aerosolized therapy because tobramycin is suspended in neutral pH (a condition similar to the respiratory lining... 

Feeley TW, du Moulin GC, Hedley-Whyte J, Bushnell LS, Gilbert JP, Feingold DS. Aerosol polymyxin and pneumonia in seriously ill patients. N Engl J Med 1975 293 471-475. 

Nebulization of antibiotics in cystic fibrosis has also been reviewed (162). For P-lactams, an improvement in pulmonary function was demonstrated with carbenicillin (163). For polymyxin, colistin alone (164), or in conjunction with oral ciprofloxacin (165), there was a decrease in the rate of decline in pulmonary function and in the Ifequency of P. aeruginosa recovered from respiratory tract secretions. Antibiotics of this class have been reported to cause bronchospasm and respiratory failure (166). Aminoglycosides have been administered as aerosols since 1950, and they have demonstrated improvement of pulmonary function, decreased sputum bacterial density, no ototoxicity or renal toxicity, and according to Smith and Ramsey (162), they are of clinical benefit for patients with cystic... 

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