Polymethacrylate copolymer

A polymethacrylate copolymer is modified by successive reaction with epichlorohydrin, w-aminophenylboric acid, and nitric acid to introduce a 1-amino-(2 -nitrophenyl-5 -boric acid)-2-hydroxyl-3-o-propyl group. The modified polymethacrylates are used as chromatographic support materials and can be used to analyze biological materials without prior deproteinization (35). 

Over the years it has been shown that complexes prepared from organophosphorous ligands in combination with peroxotungstic acid or its quaternary ammonium salts exhibit efficient catalytic properties. In order to make an efficient recycling of the catalyst possible and get tungsten-free products and effluents, some of these catalysts were immobilized onto polystyrene, poly benzimidazole and polymethacrylate copolymers modified by the introduction of the phosphorous(V)-containing ligands. 

Polyacrylate-polymethacrylate copolymers (Eudragits) are widely used as tablet adjuvants and coating polymers [1]. These polyacrylate polymers were also used for the microencapsulation of... 

Crosslinkable polymethacrylate copolymers, (III), prepared by Yamamoto (6) were effective as optical waveguide devices. 

Similarly, the syntheses of polymethacrylate-h-poly(ethylene oxide), poly-methacrylate-fc-poly(methacrylic acid) and polymethacrylate-h-polysiloxane-h-polymethacrylate copolymers were achieved by end group transesterification of polymethacrylates prepared by radical polymerization in the presence of mer-captans [128]. 

Polymethacrylate copolymers are widely used as film-coating materials in oral pharmaceutical formulations. They are also used in topical formulations and are generally regarded as nontoxic and nonirritant materials. 

The first PFS-fr/ock-polymethacrylate copolymer was reported in 2002 28 The procedure involved a two-step anionic polymerization (Scheme 3.7). Hydroxy terminated polyferrocenylsi-lane (PFS-OH) was initially synthesized using r-butyldimethylsilyloxy-1-propyllithium as an initiator bearing a protected alcohol functionality. Once isolated, PFS-OH was deprotonated using potassium hydride to afford the alkoxy chain end that initiates dimethylaminoethyl methacrylate (DMAEMA) for anionic polymerization. The PFS- -PDMAEMA block copolymer was obtained in a high yield (Mn = 11,000 PDI =1.3) and with a low polyferrocenylsilane content (PFS PDMAEM A = 1 5). 

In stiU another subsequent work, Zhao and coworkers [237] used block copolymers composed of polystyrene and liquid crystalline azobenzene-containing polymethacrylate copolymers as a model system... 

The advancing CAs of both water and hexadecane on surfaces of sf-polymethacrylate copolymers with different side chains and molar content of the /-methacrylate show clear influences of both (Figures 11.23a and 11.23b). Note that all thin films on silicon wafer with very low roughness as ensured by ellipsometry and X-ray reflectivity were prepared under comparable conditions by spin-coating from BFMB or chloroform, followed by drying in a vacuum oven at 140°C for several hours. 

Polymethacrylate copolymers lack the solubilizing capacity of other polymers, but are excellent matrix formers, used for the sustained release of drugs, or for enteric release, depending on polymer chemistry. The ammonio-methacrylate copolymers (Eudragit RS/RL) are insoluble but permeable by water, a property that makes them suitable for the production of sustained release pellets. Poly(methacrylic acid-co-methyl methacrylate) 1 2 (Eudragit S) and Poly(methacylic acid-co-ethyl acrylate) 1 1 (Eudragit L), on the other hand, are soluble at pH values above 6 and 7 respectively, which makes them suitable for enteric release pellets. 

Li Y, Ikeda S, Nakashima K, Nakamura H (2003) Nanoaggregate formation of poly(ethylene oxide)-b-polymethacrylate copolymer induced by cationic anesthetics binding. Colloid Polym Sci 281 562-568... 

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