Enzyme responsive polymer conjugates

Enzyme-responsive polymer conjugates are typically block polymers of an artihdal polymer and a polypeptide. Three strategies have been explored to prepare polymer-polypeptide conjugates. Firstly, the artificial polymer (e.g., PEG/PEO) can be immobilised on a solid support and terminated with an amine group (Fig. 6.11). This makes direct SPPS of the polypeptide... 

Besides the chemoenzymatic approaches described above, where functional groups are added to allow for conjugation with other macromolecules, enzymes demonstrate other possibilities to obtain peptide- and protein-polymer conjugates, which are normally difficult to obtain by common chemical synthetic strategies. Enzyme responsiveness can be used to modulate bioconjugate properties in order to create hybrid materials with... 

An interesting application of polymer protein conjugates has been reviewed by Alexander et al. [75,76]. By connecting stimulus responsive synthetic polymers to enzymes, the enzyme activity could be directed by varying temperature or by UV illumination, since this resulted in a change in hydro-dynamic volume of the polymers attached [77]. In general, the attachment of polymer chains proved to stabilize the enzymes. In case of the prote-... 

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