Polymers biocompatibility

Composition Acrylic hydrophilic network polymer, biocompatible... 

VS. 3 of 13 local bolus infusion animals p < 0.01) and no cures in other study groups. Follow-up study confirmed cisplatin-loaded polymer biocompatibility (36). 

Buddy Ratner s interests include biomaterials, tissue engineering, polymers, biocompatibility, drug delivery, surface analysis, self-assembly, nanobiotechnology, RF-plasma thin film deposition and biomaterials education. He has participated in the launch of six companies based on technologies from his laboratory, and serves as a consultant for numerous other companies. 

Looking to establish structure-property relationships in a different biological context, Kohn et al and Effah-Kaufmann and Kohn also examined the impact of their polyarylate library on the proliferation of UMR-106 osteoblast-like cells and fibrinogen adsorption as a measure of polymer biocompatibility. An analysis of total DNA concentration as well as metabolic and alkaline phosphatase activity after exposure of UMR-106 osteoblast-like cells to polyarylates revealed no noticeable cytotoxicity, with alkaline phosphatase and metabolic activities equivalent to that observed with tissue culture polystyrene. Polymers containing short ethyl ester side chains stimulated cell proliferation more effectively than more hydro-phobic ester side chains, while no correlations were observed between cell growth and strurtural features of the polymer backbone. 

Key words resorbable polymer, biocompatibility, hydrolytic degradation, enzymatic degradation, mechano-active tissue engineering, elastomeric properties, copolymerization, particulate leaching, gel spinning. 

Gilding, D.K., 1981. Biodegradable polymers. Biocompatibility of Clinical Implant Materials 2,... 

PPy is the first and most extensively studied and used CP for biomedical and tissue engineering applications [241-245]. It was one of the first known polymers biocompatible to cells both in vitro and in vivo and promoting their adhesion and growth in vitro. PPy implants have also shown to be compatible with minimum or no response from tissues. The electrical stimulation of PPy has also been found to... 

Anderson, J.M., Spilizevs ski, K.I.. and Hiltner, A. (1985) Poly-a amino acids as biomedical polymers. Biocompatibility of Tissue Analogs. Boca Raton, CRC Press Inc. (V7-88. 

Enhancement of Polymer Biocompatibility. Films from about 0.5 g. of polymer were cast as for the water pickup determinations. The dry films were placed in 100 ml. of deionized water and left at ambient temperature. The water was changed every 24 hours for a total of 72 hours. The films were dried in vacuo at 50°C. Then the... 

Enhancement of Polymer Biocompatibility. The polymers as initially prepared were all found to be cytotoxic, most likely due to residual catalyst in the polymer. The extraction scheme was desiped to remove water and organic extractable materials. After following the extraction scheme, all of the polymers passed the cytotoxicity screen. 

Polymer surfaces play an important role in many polymer applications especially biomaterials. The design and synthesis of desired surface properties of biomedical polymers are among our approaches to biomedical polymers. Biocompatibility was defined in 1987 as the ability of a material to perform with an appropriate host response in a specific application . Bulk and surface properties of biomaterials used for implant devices directly influence the tissue interface dynamics from initial implantation until explantation. The most important influence on how proteins, cells, and the organism respond to a material is the surface structure, in both chemical and morphological terms. 

D.K. Gilding, "Biodegradable polymers , Biocompat. Clin. Impant. Mater., 2,209-232, 1981. 

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