Biocompatibility of Biodegradable Polymers

Over the past two decades, the trend of using biodegradable materials instead of biostable materials has rapidly emerged in the case of various applications [44]. Because of the diverse features of polymeric materials, biodegradable polymers are rapidly replacing other materials such as metals, alloys, and ceramics [45]. This tremendous increase in the use of biodegradable materials supports the prediction that many of the permanent prosthetic devices used currently will be replaced by biodegradable devices in 

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Cytotoxicity is the most important parameter to evaluate the biocompatibility of biodegradable polymers in vitro. Various assays are available to measure cell viability after exposure to polymer extracts, such as lactate dehydrogenase leakage assay (LDH), neutral red uptake assay (NRU), and trypan blue assay. Table 20.5 summarizes the different types... 

The assessment of the biocompatibility of biodegradable polymers takes into account the incidence of the inflammatory and healing responses of the injected and implanted biomaterials [58],... 

As was previously explained, the assessment of the biocompatibility of biodegradable polymers takes into account the incidence of the inflammatory and healing responses of the injected and implanted biomaterials [58]. Research has pointed out that PLGA delivery devices that contain different agents are biocompatible and do not exhibit undesirable reactions when used in therapeutic applications in vivo. 

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