Polymeric immunoglobulin receptor

Ferkol T, Perales JC, Eckman E, Kaetzel CS, Hanson RW, Davis PB (1995) Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor 200. J Clin Invest 95 493-502... 

Leung JC, Tsang AW, Chan DT, Lai KN. Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells. J Am Soc Nephrol 2000 ll(2) 241-9. 

Zhang JR, Mostov KE, Lamm ME, et al.The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells. Cell 2000 102(6) 827-37. 

Elm C, Braathen R, Bergmann S, et al. Ectodomains 3 and 4 of human polymeric Immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. I Biol Chem 2004 279(8) 6296-304. 

The vitamin B12 receptor which facilitates uptake of the vitamin-intrinsic factor vitamin-binding protein complex has been used to enhance oral delivery and gastrointestinal uptake of peptides and proteins as their vitamin B12 conjugates (37). Commercial efforts are under way to exploit this receptor as well as the fetal Pc receptor which facilitates intestinal uptake of antibodies from colostrum/milk (38) and the polymeric immunoglobulin receptor which facilitates the serosal to mucosal transport of IgA and IgM (39). 

Apodaca G, Mostov KE. Transcytosis of placental alkaline phosphatase-polymeric immunoglobulin receptor hision proteins is regLilated by mutations of Ser664. J Biol Chem 1993 268 23712-9. 

De Groot, N., van Kuik-Romeijn, P., Lee, S.H., and De Boer, H. (1999). Over-expression of the murine polymeric immunoglobulin receptor gene in the mammary gland of transgenic mice. Transgenic Res. 8,125-135. 

Ferkol, T., Pellicena-Palle, A., Eckman, E., Perales, J. C Trzaska, T., Tosi, M., Redline, R., and Davis, P. B. (1996) Immunologic responses to gene transfer into mice via the polymeric immunoglobulin receptor. Gene Ther. 3(8), 669-678. 

First contact between the intestinal microbiota and the host occurs via mucosal ECs (or modified epithelial cells called M cells in the Peyer s Patches), and underlying or intercalating DCs. Mucosal ECs express polymeric immunoglobulin receptor (PigR) and secretary component, MHC class I and II molecules, other adhesion molecules and a variety of cytokines and chemokines. These molecules play important roles in signaling microbial... 

Sarkar J, Gangopadhyay NN, Moldoveanu Z, Mestecky J, Stephensen CB (1998) Vitamin A is required for regulation of polymeric immunoglobulin receptor (plgR) expression by interleukin-4 and interferon-y in a human intestinal epithelial cell line. 7 Viitr 128 1063-1069... 

Genetransferintotheairway epithelium of animals by targeting the polymeric immunoglobulin receptor. J Chn Invest 2001 95 493-502. 

ROMBOUT JH, VAN DER TUIN SJ, YANG G, SCHOPMAN N, MROCZEK A, HERMSEN T, TAVERNE-THIELE jj (2008), Expression of the polymeric Immunoglobulin Receptor (pIgR) in mucosal tissues of common carp (Cyprinus carpio L.) , Fish Shellfish Immunol, 24, 620-8. 

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