Polymer lactide-based

The internal hydrophobic core of lipospheres is composed of fats and biodegradable polymers, mainly triglycerides and lactide-based polymers, whereas the surface activity of liposphere particles is provided by the surrounding lecithin layer, composed of phospholipid molecules. 

Chemical Composition and Physical Properties of T57pical High Lactide-Based Polymers... 

Espino-PCTez, E., Bras, J., Ducruet, V., Guinault, A., Duffesne, A., Domenek, S. Influence of chemical surface modification of cellulose nanowhiskers on thermal, meehanical, and barrier properties of poly(lactide) based bionanoeomposites. Eur. Polymer J. 49, 3144-3154 (2013)... 

W. Wang, P. Ping, X. Chen, X. Jing, Shape memory effect of poly(L-lactide)- based polyurethanes with different hard segments, Polym. Int. 56 (2007) 840-846. 

H. Tsuji, Degradation of poly(lactide)-based biodegradable materials, in L. B. Albertov (Ed.), Polymer Degradation and Stability Research Developments, Nova Science Publishers, New York, 2007, pp. 11-59. 

Nanocapsules can be formulated from a variety of synthetic or natural monomers or polymers by using different techniques in order to fulfill application requirements. For example, by interfacial deposition of the preformed polymer, poly(D,L-lactide)-based nanocap-... 

Summary of current research papers on miscibility studies of polymer blends based on poly(lactide) (PLA). 

Ema, Y, Ikeya, M., and Okamoto, M., 2006. Eoam processing and cellular strucuture of poly-lactide-based nanocomposites. Polymer 41 5350-59. 

Bandyopadhyay, S., Chen, R. and Giannelis, E.P. 1999. Biodegradable organic-inorganic hybrids based on poly(L-lactide). polymer material science engineering 81 159-160. 

Paul, M., Alexandre, M., Degee, P., Henrist, C., Rulmont, A., and Dubois, P. 2002. New nanocomposite materials based on plasticized poly(L -lactide) and organo-modified montmorillonites thermal and morphological study. Polymer 44 443-450. 

Pego AP, Siebum SB, Luyn MJAV, et al. Preparation of degradable porous structures based on 1,3-trimethylene carbonate and D,L-lactide(co)polymers for heart tissue engineering. Tissue Eng, 2003, 9, 981 994. 

Sterilization of the finished drug delivery formulation is an important consideration often overlooked in the early design of lactide/glycolide delivery systems. Aseptic processing and terminal sterilization are the two major routes of affording an acceptably sterile product. Both of these methods are suitable for products based on lactide/glycolide polymers if proper care is exercised in processing or selection of the treatment procedures. 

FIGURE 4 Controlled release systems based on lactide/glycolide polymers with duration of action of a few days to 1 year. 

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