Polymer-Ferrocene Conjugates Synthesis and Structure

During the three decades following the discovery of ferrocene in 1951, the literature cited an extraordinarily large number of pubhcations in the area of polymeric ferrocene compounds, as scientists embarked on a search for new properties and applications of the metallocene that would be specifically associated with the polymer-bound, yet not with the monomeric, compound. A special type of polymer used in space technology, a linear construct in which ferrocene nuclei are interconnected by simple methylene bridges, represents just one example of these early endeavors. Whenever linear and essentially free from rotational restrictions, these polymeric, and quite lipophilic, ferrocenes were generally reported to possess solu-bihty in a restricted number of organic solvents, yet certainly not in water. 

One of the most attractive polymer types to serve as drug carriers in accordance with the principles outlined in the foregoing is represented by the class of 

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