Polymer-Assisted Technologies in Multistep Solution-Phase Syntheses

POLYMER-ASSISTED TECHNOLOGIES IN MULTISTEP SOLUTION-PHASE SYNTHESES 

Bifunctionally tagged Mitsunobu reagents 21 and 22, quaternary ammonium carbonate resin 65, tetrafluorophthalic anhydride (as a solution-phase linking reagent), and amine-functionalized resin 2 were used in a three-step solution-phase synthesis of a series of substituted hydroxypiperidines.39 No further purification (e.g., liquid-phase extraction or chromatography) was required, and products were isolated in good yields and purities. 

Polymer-assisted solution-phase synthesis offers strategies for chemical library construction that complement solid-phase methods. Tools now available include chemoselective sequestering resins, bifunctional solution-phase linking reagents, bifunctional chemically tagged reagents, and an 

Gordon, E. M Gallop, M. A. Patel, D. V. Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery, Acc. Chem. Res. 

Thompson, L. A. Ellman, J. A. Synthesis and Applications of Small Molecule Libraries, Chem. Rev. 1996, 96, 555. 

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