Polymer-assisted solution phase synthesis acid chloride resin

The field of organic chemistry has seen the most extensive use of polymeric materials as aids in effecting chemical transformation and product isolation. Insoluble polymer supports have been used as handles to facilitate these functions. As chemical reagents can be bound to an insoluble polymer carrier and used in organic synthesis [117,118], polymer-bound reagents can also be used to assist in the purification step of solution-phase reactions [119,120]. The latter are known as scavenger resins. These are added to the reaction mixture upon completion of the reaction in order to quench and selectively bind to the unreacted reagents or by-products. The polymer-bound impurities are then removed firom the product by simple filtration to obtain pure compounds. For example, aminomethylated poly(styrene-co-divinyl benzene) can be used to remove acid chlorides, sulfonyl chlorides, isocyanates, thiocyanates, and proton. Similarly, 2-Chlorotrityl resins have been developed for the attachment of carboxylic acids, alcohols. 

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