Polyethyleneglycol polymer-supported synthesis

The foregoing typical results clearly illustrate another very important application of the polyethyleneglycol support method for the synthesis of peptides and protein sequences. The unique suitability of this linear, soluble macromolecular support with optimum hydrophilicity-hydrophobicity balance for the conformational analysis of the bound peptides originates from the peculiar conformational properties of the polymer chain. [Pg.163]

Unlike reagents bound to crosslinked polymeric supports, soluble macromolecules are able to interact with reactive groups attached to insoluble polymers. This fact was demonstrated by Frank and Hagenmaier, who developed an alternating liquid-solid phase peptide synthesis procedure. Amino acids attached to crosslinked polystyrene via a carbamate linker were condensed with a peptide ester of polyethyleneglycol monostearylether (Scheme 1.6.12). [Pg.52]