Polyethylene glycol monomethyl ether MPEG

The same 2-0-acetyl-protected mannosyl trichloroacetimidate was used in a polymer-supported solution-phase synthesis of a tetramannose moiety with polyethylene glycol monomethyl ether (MPEG) as polymer-support [196], The use of controlled-pore glass (CPG) as solid-phase support is under investigation in the synthesis of oligosaccharides [197] and glyconucleotide conjugates [198] with trichloroacetimidates as donors. 

MC MDI MEKP MF MMA MPEG MPF NBR NDI NR OPET OPP OSA PA PAEK PAI PAN PB PBAN PBI PBN PBS PBT PC PCD PCT PCTFE PE PEC PEG PEI PEK PEN PES PET PF PFA PI PIBI PMDI PMMA PMP PO PP PPA PPC PPO PPS PPSU Methyl cellulose Methylene diphenylene diisocyanate Methyl ethyl ketone peroxide Melamine formaldehyde Methyl methacrylate Polyethylene glycol monomethyl ether Melamine-phenol-formaldehyde Nitrile butyl rubber Naphthalene diisocyanate Natural rubber Oriented polyethylene terephthalate Oriented polypropylene Olefin-modified styrene-acrylonitrile Polyamide Poly(aryl ether-ketone) Poly(amide-imide) Polyacrylonitrile Polybutylene Poly(butadiene-acrylonitrile) Polybenzimidazole Polybutylene naphthalate Poly(butadiene-styrene) Poly(butylene terephthalate) Polycarbonate Polycarbodiimide Poly(cyclohexylene-dimethylene terephthalate) Polychlorotrifluoroethylene Polyethylene Chlorinated polyethylene Poly(ethylene glycol) Poly(ether-imide) Poly(ether-ketone) Polyethylene naphthalate Polyether sulfone Polyethylene terephthalate Phenol-formaldehyde copolymer Perfluoroalkoxy resin Polyimide Poly(isobutylene), Butyl rubber Polymeric methylene diphenylene diisocyanate Poly(methyl methacrylate) Poly(methylpentene) Polyolefins Polypropylene Polyphthalamide Chlorinated polypropylene Poly(phenylene oxide) Poly(phenylene sulfide) Poly(phenylene sulfone)... 

Methods The MPEG polymer (polyethylene glycol monomethyl ether, Mw approx 5000, free OH approx 0.2 mmol/g) was purified by precipitation of a DCM solution into diethyl ether. Then, the freshly precipitated polymer was dissolved in dry DCM/MeOH (50 1) and was dried by gel filtration under argon over a mixture of silica gel, magnesium sulfate, and Celite (1 0.5 1) followed by concentration under reduced pressure under argon see Note 5). 

Fig. 2. Application of the polyethylene glycol-co-monomethyl ether (MPEG) solid support with an a,a -dioxyxylyl (DOX) diether linker for oligosaccharide synthesis in solution.

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