Polycyclic aromatic hydrocarbons prenatal exposure

Perera, F.P., Tang, D., Wang, S., et al, 2012. Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years. Environ. Health Perspect. 120, 921-926. 

Perera, E.P., Rauh, V., et al (2006) Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environmental Health Perspectives, 114(8) 1287-1292. 

The goal of this chapter is to stimulate research activity to develop both novel intervention strategies and therapeutic approaches to mitigate the neurotoxicity associated with prenatal exposure to polycyclic aromatic hydrocarbons (PAHs). The focus of this chapter is PAH exposure of vulnerable populations as a result of terrorist attacks on US targets. We will attempt to define the signature of prenatal PAH exposure-induced neurotoxicity within the context of human epidemiological data and translate this to appropriate animals models. 

Edwards, S.C., Jedrychowski, W, Butscher, M., et al, 2010. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children s intelligence at 5 years of age in a prospective cohort study in Poland. Environ. Health Perspect. 118, 1326-1331. 

Perera, RR, Li, Z., Whyatt, R., et al, 2009. Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics 124, el95-e202. 

Sheng, L., Ding, X., Ferguson, M., et al., 2010. Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET. Toxicol. Sci. 118, 625-634. 

Choi, H. Jedrychowski, W. Spengler, J. Camann, D.E. Whyatt, R.M. Rauh, V. Tsai, W.-Y. Perera, F.P. 2006. International Studies of Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Fetal Growth. Environmental Health Perspectives, v.ll4, p. 1744-1750. 

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