Polycyclic aromatic hydrocarbons bioassays

Perez, S. Farre, M. Garcia, M.J. Barcelo, D. Occurrence of polycyclic aromatic hydrocarbons in sewage sludge and their contribution to its toxicity in the ToxAlert 100 bioassay. Chemosphere 2001, 45, 705-712. 

Pyrene is not classified as human carcinogen by the US Environmental Protection Agency (EPA) based on no human data and inadequate data from animal bioassays. Increased incidences of lung, skin, or genitourinary cancers were observed in workers exposed to a variety of polycyclic aromatic hydrocarbons. Prolonged exposure to coal tar pitch volatiles can cause dermatitis. 

Mayura K, Huebner HI, Dwyer MR, et al. 1999. Multi-bioassay approach for assessing the potency of complex mixtures of polycyclic aromatic hydrocarbons. Chemosphere 38(8) 1721-1732. 

These exposure estimates [for benzo[a]pyrene] and the determinations of the tumorigenic potential of [polycyclic aromatic hydrocarbons] in bioassays strongly suggest that [polycyclic aromatic hydrocarbons] play a significant role in the induction of respiratory tract cancer in smokers... 

Ziccardi M H, Gardner I A, Denison M S (2000). Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum. Toxicol. Sci. 54 183-193. 

Ciganek M, Neca J, Adamec V, Janosek J, Machala M (2004) A combined chemical and bioassay analysis of traffic-emitted polycyclic aromatic hydrocarbons. Sci Total Environ 334—335 ... 

Bellas, J. Saco-Alvarez, L. Nieto, O. Beiras, R. 2008. Ecotoxicological evaluation of polycyclic aromatic hydrocarbons using marine invertebrate embiyo-larval bioassays. Marine Pollution Bulletin, v.57, p.493-502. 

Ke, R. Li, J. Qiao, M. Xu, Y. Wang, Z. 2007. Using Semipermeable Membrane Devices, Bioassays, and Chemical Analysis for Evaluation of Bioavailable Polycyclic Aromatic Hydrocarbons in Water. Archives of Environmental Contamination and Toxicology, v.53, p.313-320. 

The polynuclear aromatic hydrocarbons are mainly formed during the combustion of tobacco. The tobacco of our standard cigarettes contains only very minute quantities of benzo(a)pyrene bic] (0.02 ppm). A bioassay indicates that these polycyclic hydrocarbons of the condensate by themselves, however, can account for not more than 3 per cent of the total biological activity. 

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