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Polyamines catabolism

Polyamine catabolism in plants, which is mediated by CAOs and PAOs, results in the formation of aminoaldehydes along with hydrogen... [Pg.1289]

Flores, H. E. and P. Fblner, Polyamine catabolism in higher plants Characterization of pyrroline dehydrogenase. Plant Growth Regul., 3, 277-291 (1985). [Pg.529]

The anti-promotion activity was shown by its blocking actimi of the stunuU-mediated MAPK pathway activation, inhibition of polyamine synthesis and increase of polyamine catabolism, and inhibition of the production of proinflammatory mediators via cyclooxygenase-2 and lipoxygenase pathways. Resveratrol may also inhibit NF-kB and AP-1 activation. [Pg.2296]

Dasu VV, Nakada Y, Ohnishi-Kameyama M, Kimura K, Itoh Y (2006) Characterization and a role of Pseudomonas aeruginosa spermidine dehydrogenase in polyamine catabolism. Microbiology 152(pt 8) 2265-2272... [Pg.57]

The Mammalian Polyamine Catabolic Enzymes and Their Metabolites... [Pg.62]

Fig. 5.1 The mammalian polyamine catabolic pathway. Spermine (Spm) is back-converted to spermidine (Spd) by either spermine oxidase SMOX) or spermidine/spermine Af-acetyltransferase SSAT) followed by acetylpolyamine oxidase APAO). Spermidine is further back-converted to putrescine Put) through the same SSAT/APAO mechanism. Both oxidation reactions generate the reactive oxygen species ROS) precursor H2O2 and aldehydes as by-products. The resulting reduction in spermine and spermidine pools implies diminished antioxidant and antiinflammatory functions... Fig. 5.1 The mammalian polyamine catabolic pathway. Spermine (Spm) is back-converted to spermidine (Spd) by either spermine oxidase SMOX) or spermidine/spermine Af-acetyltransferase SSAT) followed by acetylpolyamine oxidase APAO). Spermidine is further back-converted to putrescine Put) through the same SSAT/APAO mechanism. Both oxidation reactions generate the reactive oxygen species ROS) precursor H2O2 and aldehydes as by-products. The resulting reduction in spermine and spermidine pools implies diminished antioxidant and antiinflammatory functions...
The higher polyamines, spermine in particular, play important physiological roles in protection from oxidative stress. Enhanced polyamine catabolism reduces this protection while concomitantly generating ROS and toxic aldehyde by-products. As a result, increased polyamine catabolism, resulting from the stimuli just mentioned, has been implicated in several pathophysiological conditions, including neurological and liver disease, stroke, kidney failure, and cancer. [Pg.66]

Pneumocystis infection is also associated with upregulated polyamine catabolism. Pneumocystis opportunistically infects the lungs of immunocompromised patients and results in a decrease in alveolar macrophages. This apoptosis appears to be the result of H2O2 production by the macrophages through increased APAO activity subsequent to tlie induction of polyamine biosynthesis (Liao et al. 2009). [Pg.67]

Renal ischemia-reperfusion has been shown to induce polyamine catabolism through SSAT and SMOX in both the kidney and liver, resulting in oxidative stress and apoptosis that do not occur in SSAT-deticient animals (Zahedi et al. 2009 Zahedi and Soleimani 2011). Furthermore, endotoxin, or EPS, is a major cause of sepsis-related acute kidney injury, and injection of mice with EPS resulted in inductions of renal SSAT and SMOX. Pharmacological inhibition of polyamine oxidation or ablation of SSAT decreased renal cell damage, implicating the catalysis of... [Pg.67]

The studies described here focus on the cellular effects of toxic by-products generated through elevated polyamine catabolism however, the resulting reduction in intracellular polyamine concentrations must also be considered, as their depletion... [Pg.68]

Polyamine Catabolism as a Therapeutic Target 5.5.1 Chemotherapeutic Strategies... [Pg.69]

Babbar N, Murray-Stewart T, Casero RA Jr (2007) Inflammation and polyamine catabolism the good, the bad and the ugly. Biochem Soc Trans 35 3(X)-304 Battaglia V, Destefano Shields C, Murray-Stewart T, Casero RA Jr (2013) Polyamine catabolism in carcinogenesis potential taigets for chemotherapy and chemoprevention. Amino Adds 46 511-519. doi 10.1007/s00726-013-1529-6... [Pg.71]

Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Piietz A, Rabizadeh S, Woster PM, Sears CL, Casero RA Jr (2011) Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc Natl Acad Sci USA 108 15354-15359... [Pg.72]

Hector S, Porter CW, Kramer DL, Clark K, Prey J, Kisiel N, Diegelman P, ChenY, Pendytila L (2004) Polyamine catabolism in platinum drug action interactions between oxaliplatm and the polyamine analogue Nl, Nll-diethylnorspennine at the level of spennidine/spemiine Nl-acetyltransferase. Mol Cancer Ther 3 813-822... [Pg.72]

Hector S, Tummala R, Kisiel ND, Diegelman P, Vujcic S, Clark K, Fakih M, Kramer DL, Porter CW, Pendyala L (2008) Polyamine catabolism in colorectal cancer cells following treatment with oxahplatin, 5-fluorouradl and Nl, N11 diethylnorspermine. Cancer Chemother Pharmacol 62 517-527... [Pg.72]

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See also in sourсe #XX -- [ Pg.1382 ]



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