Poly , PHBHHx

Figure 16.6 Polyhydroxyalkanoates (PHA) that have been produced in sufficient quantity for application research, including poly-(R)-3-hydroxybutyrate (PHB), poly-4-hydroxybutyrate (P4HB), poly-3-hy-droxyoctanoate (PHO) (up part left to right). Random copolymers of (R)-3-hydroxybutyrate and (R)-3-hydroxyvalerate (PHBV), (R)-3-hydroxybutyrate and (R)-3-hydroxyhexanoate (PHBHHx), and (R)-3-hydroxybutyrate and 4-hydroxybutyrate (P3HB4HB) (bottom part left to right).

HT = hydrogenated tallow, T = tallow, PHB = poly(3-hydro butyrate), PHBHHx = poly(3-hydro-xybutyrate-co-3-hydroxyhexanoate), PHBHV = poly(3-hydro ybutyrate-co-3-hydro] alerate). 

The Achilles tendon is the largest and strongest tendon in the body. With an incidence of 12—18/100,000 per year, the Achilles tendon is also the most commonly injured tendon (Webb et al., 2013 Sheam et al., 2011 Freedman et al., 2014). For the regeneration of Achilles tendon, Webb et al. (2013) developed a hybrid poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and collagen scaffold (Fig. 17.7). PHBHHx belongs to a family of polyhydroxyalkanoate biopolymers... 

PHB, PHBV, P4HB (short for poly-4-hydroxybutyrate), PHBHHx and poly-3-hydroxoctanoate (PHO), which are available in sufficient quantities, have been... 

NaOH treatment could significantly enhance the blood compatibility of PHBHHx by prolonging plasma recalcification time, plasma prothrombin time, and kinetic clotting time and by decreasing platelet activation. By comparison, PHBHHx exhibited a substantially better blood compatibility than poly(L-lactic acid) [58]. 

Ye et al. have looked into PHB scaffolds, and worked on the potential of PHB/poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) (PHB/ PHBHHx) to produce neocartilage upon seeding with differentiated human adipose-derived stem cells (hASCs). The study demonstrated that PHB/ PHBHHx was a suitable material for cartilage tissue engineering. " ... 

The most typical PHA family member is PHB which is a scl PHA scl PHA includes also poly(hydroxybutyrate-co-hydroxyvalerate) or P(HB-co-HV) or PHBV. Scl PHA is normally brittle (Fig. 2.8). The most typical mcl PHA is P(HO-co-HD), which is elastic in property (Fig. 2.8). Copolyester of hydroxybutyrate and hydroxyhexanoate or abbreviated as P(HB-co-HHx) or PHBHHx, combines the properties of scl- and mcl PHA and becomes a real... 

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