Poly-p-benzyl-L-aspartate

Kataoka K, Matsumoto T, Yokoyama M et al (2000) Doxorubicin-loaded poly(ethylene glycol)-poly(P-benzyl-L-aspartate) copolymer micelles their pharmaceutical characteristics and biological significance. J Control Release 64 143-153... 

On the other hand, the dilute solution of poly(p-benzyl-L-aspartate) in chloroform or dichloromethane gives a weak but existant CD band centered at 252 nm. A large positive CD band at 222 nm means that poly(p-benzyl-L-aspartate) (PBLA) exists in the left-handed a-helical form. Poly(y-p-nitrobenzyl-L-glutamate) also shows a definite negative CD band around 275 nm, even if the concentration of the polymer... 

However, only limited experimental studies on the thermodynamic properties of polypeptide solutions have been carried out. The results of vapor sorption studies for PBLG and poly(P-benzyl L-aspartate) solutions at high polymer concentrations by Flory and Leonard could not be explained by the Flory model, but could be explained by assuming that mixing of solvent with flexible side chains dominates the thermodynamic behavior at high concentrations. Rai and Miller obtained similar results for the PBLG-dimethylformamide (DMF) system at high concentrations. They also showed that the results could be explained by the Wee-MiUer theory in which modification of Flory s lattice theory to allow for side chain... 

Kwon, G. S., Naito, M., Yokoyama, M., Okano, T., SakuraL Y., Kataoka, K., 1993, Micelles based on AB block copolymers of poly(ethylene oxide) and poly(P benzyl L-aspartate). Langmuir 9 945-949. 

Partial specific volume of poly(p-benzyl-l-aspartate)... 

Brule B, Zagar E, Gadzinoski M, Slomkowski S, Zigon M (2011) Homo and block copolymers of poly(P-benzyl-L-aspartate)s and poly(y-benzyl-L-glutamate)s of different architectures. Macromol Chem Phys 212 550-562... 

Poly(P benzyl-L-aspartate) (PBLA) in the solid state adopts various conformations such as a right-handed a(ttR) helix, a left-handed a(aj helix, a left-handed CO(cOl) helix and a P sheet form, depending on the temperature. VT C CP MAS NMR spectra of PBLA are shown in Figure 8. From this, it is clear that the conformational changes such as aR helix COl helix P sheet occur with increasing temperature. 

Poly(P-benzyl-L-aspartate), see Poly(iminocarbonyl-L-benzyloxycarbonylethylidene) Poly(Y-benzyl-L-glutamate), see Poly(iminocait)onyl-L-benzyloxycarbonylpropylidene) Poly[(benzylimino)carbonylethylene], (Poly(AI-benzyl-p-alanine))... 

Poly(iminocarbonyl-L-benzyloxyearbonylethylidene), (Poly(P-benzyl-L-aspartate)) ... 

---