Poly-n-butylcyanoacrylate

Johnston and Pepper have succeeded in quantifying the reactivity of poly-(n-butylcyanoacrylate) carboanion in THF. Their derived value for kp(- )... 

The system consists of hollow spheres made up from the polymer poly-n-butylcyanoacrylate which are filled with a triglyceride oil component and dispersed in an aqueous phase in presence of a surfactant. While the capsule walls are only a few nanometers thick, the capsule radius varies between 100 and 200 nm. A cross-... 

Fig. 26. Experimental ( H)- C cross-polarization spectra of an aqueous dispersion of poly-n-butylcyanoacrylate nanocapsules at different mixing periods tc. The spectra are measured at a resonance frequency of Wc 100 MHz after contact times of cp O.l, 0.25 and 0.5 ms under full proton decoupling. The wide lines derive from the polymer forming the capsule membrane while the narrow lines are assigned to the triglyceride oil. At cp = 0.25 ms, the broad signals of the polymer have almost developed to their full intensity, whereas the signals of the oil still gain amplitude. ...

Fig. 37. Comparison between enlarged sections of direct excitation spectra of dispersed poly-n-butylcyanoacrylate nanocapsules after 3 h annealing at 130°C (top line) and a solution of n-butylcyanoacrylate in CHCI3 (bottom line). The new signals appearing after the thermal treatment a, b, c, and d may be assigned to traces of the monomer resulting from the depolymerization of the capsule wall material. The shift variation observed for the carbonyl carbon signal (a) may result from an interaction with the solvent. The assignments to the monomer carbons are given in the insert. ...

Crespy D, Landfester K (2005) Anionic polymerization of E-caprolactam in miniemulsion synthesis and characterization of polyamide-6 nanoparticles. Macromolecules 38 6882-6887 Weiss CK, Ziener U, Landfester K (2007) A route to nonfunctionalized and functionalized poly(n-butylcyanoacrylate) nanoparticles preparation in miniemulsion. Macromolecules 40 928-938... 

Weiss CK, Lorenz MR, Landfester K, et al. (2007) Cellular uptake behavior of unfunctionalized and functionalized poly(n-butylcyanoacrylate) particles prepared in a miniemulsion. Macromol Biosci 7 883-896... 

Yordanov G, Abrashev N, Dushldn C (2010) Poly(n-butylcyanoacrylate) submicron particles loaded with ciprofloxacin for potential treatment of bacterial infections. Prog Colloid Polym Sci 137 53-59... 

Abstract Monodispersed biodegradable poly(n-butylcyanoacrylate) nanocapsules containing DNA molecules (790 base pairs) within an aqueous core were prepared by anionic polymerization of n-butyl-cyanoacrylate at the droplets interface in inverse miniemulsion. The aqueous droplets in the size range of 300-700 nm dispersed in the hydrophobic continuous phase were formulated using the miniemulsion technique that allows an easy control of the droplet size and size distribution. After polymerization, the capsules were transferred into an aqueous phase. The effect of several reaction parameters such as the amount of monomer, type of the non-ionic surfactant (i.e. Span 80 and Tween 80) and type of the continuous phase (i.e. Miglyol 812N and... 

The poly(alkylcyanoacrylate) nanospheres, widely used as drug carriers, are prepared by emulsion polymerization according to a method initially introduced by Couvreur et al. The monomers (isobutylcyano-acrylate, isohexylcyanoacrylate, n-butylcyanoacrylate) are dispersed in a continuous acidified aqueous phase under magnetic agitation. The anionic polymerization... 

Fig. 16. Experimental C direct excitation spectra of an aqueous dispersion of poly-u-butylcyanoacrylate nanocapsules (top) and of reference samples of liquid and dissolved constituents (a aqueous solution of the block-copolymer surfactant Pluronic F68 b the liquid oil component Miglyol 812 used as capsule content c the liquid monomer u-butylcyanoacry-late). " All spectra are measured at a resonance frequency of wc 100MHz under full proton decoupling. In the spectrum of the dispersion, no narrow signals occur at the positions of the n-butylcyanoacrylate resonances (vertical arrows), indicating the complete absence of the monomer after the formation of the capsules. For the capsule dispersion, a slight increase in line width is observed for the characteristic resonances of the liquid components.

Fig. 35. C-NMR-spectra of aqueous dispersions of poly- -butylcyanoacrylate nanocapsules after 3 h of annealing at different temperatures (a) 50°C, (b) 100°C, (c) 130°C. The ( H)- C crosspolarization spectra (tcp = 1 ms, left column) indicate the loss of the solid capsule wall at higher temperatures (see also Fig. 36). The narrow signals superimposed on the solid-state spectrum of the polymer derive partially from the adsorption of the triglyceride oil and the surfactant to the capsule surface (compare Section 4.4), partially from the residual cp in the liquid phase. The direct excitation spectra (right column) show the liquid and dissolved components with an increasing indication for traces of the n-butylcyanoacrylate monomer which results from depolymerization of the capsule wall material (arrows, see also Fig. 37). ...

Heterogeneous polymerization Precipitation Emulsion Dispersion PNIPAM microgel nanoparticles Poly(PNIPAM-co-AA) microgel nanoparticles NPs based on poly(butyl methacrylate) core and PNIPAM shell Colloidal nanospheres of poly(butylcyanoacrylate) with a magnetite core Pegylated NPs composed of N,N- diethylacrylamide and N,N-methylene bisacrylamide Berndt et al., 2006 Jones and Lyon, 2000 Gan and Lyon, 2003 Arias et al., 2008 Rieger et al., 2009... 

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