Poly-N-acylated amines

Non-natural peptides involved in the stabilization of the MFIC class I molecules can be considered as the starting point for the discovery of new immune modulators such as antitumor vaccines and T-cell receptor agonists or antagonists [44-48]. In this context, poly-N-acylated amines (PAAs) as a new class of synthetic oligomers were developed and tested as ligands for the murine class I molecule H-2Kb [49]. Based on the natural cytotoxic T-cell epitope SIINFEKL, non-peptidic structural elements were introduced in the C-ter-minal part of the ligand including the anchor positions 5 (Phe) and 8 (Leu) (Fig. 7.7). 

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Scheme 7.6. Scheme for the automated parallel synthesis of poly-N-acylated amines exemplified for one defined compound, e.g., PAA oligomer 12 exhibiting high binding affinity to MHC class 1 molecule H-2Kb [49]. 

Figure 7.7. Molecular structures of three potential MHC class I ligands consisting of poly-N-acylaled pep-tidic amines (PAA).

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