Poly ethylene glycol doxorubicin encapsulated

Since the discovery of vesicular structures, termed liposomes, by Alec Bangham, a tremendous amount of work on applications of liposomes has emerged. The use of small unilamellar liposomes as carriers of drugs for therapeutic applications has become one of the major fields in liposome research. The majority of these applications are based on the encapsulation of water-soluble molecules within the trapped volume of the liposomes. Long circulating poly(ethylene glycol) (PEG) modified liposomes with cytotoxic drugs doxorubicin, paclitaxel, vincristine, and lurtotecan are examples of clinically applied chemotherapeutic liposome formulations (1,2). 

Parr, M. J., Masin, D., Cullis, P. R., Bally, M. B., 1997, Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma The lack of beneficial effects by coating liposomes with poly(ethylene glycol). J. Phamacol. Exp. Then 280 1319-1327. 

Several anti-cancer drugs can be incorporated in polymer nanofibers for subsequent sustained release into the surrounding microenvironment. To date, paclitaxel is the agent most widely investigated in this framework. " Doxorubicin has also been studied as a model for encapsulation within biodegradable nanofibers of poly(ethylene glycol)-PLA copolymers. " ... 

Also aiming at biomedical applications are nanoscaled hydrogels, prepared in inverse miniemulsion. In crosslinked poly(oligo(ethylene glycol) monomethyl ether methacrylate) (POEOMA) nanogels hydrophilic dyes as the polymeric dye (rhodamine isothiocyanate (RITC) dextran) [41], rhodamine in combination with the drug doxorubicin [42] or gold nanoparticles with bovine serum albumin [43] could be encapsulated. 

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