Pneumonia gram-positive bacteria

The emergence of multidrug-resistant Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and vancomycin-resistant enterococci... 

The DKPs cyclo(His-Ala) and cyclo(His-Gly) proved to have promising anticancer activity comparable with that observed for cisplatin. Cyclo(His-Ala) in particular demonstrated an ability to inhibit tumor growth in HT-29, HeLa, and MCF-7 cancer cell lines. Cyclo(His-Gly) however, only had a marked effect on MCF-7 carcinoma cells at a concentration of 100 pmol 1. Both DKPs at a concentration of 0.5 mmolwere effective against two of the three Gram-positive bacteria, that is, Bacillus and S. aureus. Cycfo(His-Gfy) was more effective against Klebsiella pneumoniae than cyclo(His-Ala). Cyclo(His-Afa) and cycfo(His-Gfy) inhibited the growth of C. albicans by 66.3 and 47%, respectively. 

It is difluorinated quinolone effective against gram positive bacteria, anaerobes and mycobacteria. It is used in the treatment of pneumonia, chronic bronchitis, sinusitis etc. 

The cell walls of Gram-positive bacteria, including the pathogens S. aureus. Bacillus anthracis. Streptococcus pneumoniae, and Enterococcus faecalis contain thick layers of peptidoglycan. The peptidoglycan layers serve as both a protective barrier and as a scaffold for the attachment of secondary cell wall polymers and surface proteins. Surface proteins include hydrolytic enzymes involved in peptidoglycan turnover, as well as structures such as pili... 

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