Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Platinum dichloro complex

Salvadori, R, Uccello-Barretta, G. and Lazzaroni, R. (1990) A new method for the enantiomeric excess determination of chiral trisubstituted allenes by 195Pt NMR of traKi-dichloro[(S)-a-methylbenzylamine](allene)platinum(II) complexes. /. Chem. Soc. Chem. Commun., 1121-1123. [Pg.65]

The p7fa s of several platinum aqua complexes are given in Table 3. From the data of Tables 1-3, all cA-dichloro compounds appear to have a... [Pg.224]

Vaughan, M. D., Robertson, V. J. and Honek, J. F. (2007) Experimental and theoretical studies on inversion dynamics of dichloro(L-difluoromethionine-V,5 )platinum(II) and dichloro(L-trifluoromethionine-V,5 )platinum(II) complexes. J. Fluorine Chem., 128, 65-70. [Pg.462]

Spectroscopic and crystallographic studies of platinum-base complexes give some insight into the reactivity of the platinum compounds and their possible binding sites on DNA. The reactions of the different nucleosides or nucleotides with the chloro and aquo derivatives of O Cs- and trans-DDP have been studied by UV spectroscopy (36), raman difference spectrophotometry (37) and high pressure liquid chromatography (38). For both chloro isomers, the rates of the reactions with various nucleic acid monomers show the following trend GMP > AMP > CMP and dG > dA > dC T, The dichloro and diaquo derivatives react slowly with thymidine and UMP (37) or not at all (38, 39). [Pg.89]

The stoichiometry of the platinum-base complex depends on the Pt base ratio and also on the pH. For instance, it has been shown that the aia-diaquo species reacts with adenine, adenosine and AMP to give 1 1, 1 2 and 2 1 (Pt base) complexes. Similar results have been observed for the trans isomer except that the 1 2 complexes with adenosine and AMP were not formed (40). The diaquo and dichloro species of cis- and trans-DDP bind to GMP and dGMP to give 1 1 and 1 2 complexes as shown by raman spectroscopy (41) and NMR (42). Cis-[Pt(NH3)2(H20)2] forms a 1 2 complex with cytidine or uridine at acid pH whereas under neutral conditions the 1 1 complex is formed (43). It also reacts with GpG and GpC forming a bidentate complex with the two bases (44). [Pg.89]

Iproplatin [CHIP, cis-dichloro-trans-dihydroxo-bis(isopropylamine) plati-num(iv) see Figure 1 for structure], like carboplatin, was selected for clinical evaluation because of its favourable efficacy profile in preclinical studies, i.e. less nephrotoxicity but antitumour activity comparable to that of cisplatin. Iproplatin was the first quadrivalent platinum(iv) complex possessing an octahedral configuration, rather than the square-planar configuration of cisplatin and... [Pg.111]

Kapoor P, Lovqvist K, Oskarsson A (1998) Cis/trans influences in platinum(ll) complexes X-ray crystal stmctures of cis-dichlorD(dimethyl sulfide)(dimethyl sulfoxide)platinum(II) and cis-dichloro(dimethyl sulfide)(dimethyl phenyl phosphine)platinum(ll). J Mol Struct 470 39-47... [Pg.225]

An early, illustrative example of the use of chiral organometallic complexes in organic chemistry was the resolution of ra/u-cyclooctene by fractional crystallization of the diastereoisomeric tra/7i-dichloro[( + )- or (- )-a-methyl-benzylamine]platinum(Il) complexes of this olefin followed by removal of the metal with aqueous potassium cyanide (Cope et al., 1963). [Pg.72]

Ohya, Y., Masunaga, T., Baba, T., Ouchi, T., 1996, Synthesis and cytotoxic activity of dextran carrying cis-dichloro(cyclohexane-trans-l-1,2-diamine) platinum(II) complex. J. Biomater. Sci. PolymerEdn. 7 1085-1096. [Pg.175]

The mechanism of redox isomerization of a/-dichloro-6c-bis(pyridine)-ffe-trimethyleneplatinum(iv) (5) to the platinum(n) complex of pyridinium... [Pg.83]

Molecules having only a sulfoxide function and no other acidic or basic site have been resolved through the intermediacy of metal complex formation. In 1934 Backer and Keuning resolved the cobalt complex of sulfoxide 5 using d-camphorsulfonic acid. More recently Cope and Caress applied the same technique to the resolution of ethyl p-tolyl sulfoxide (6). Sulfoxide 6 and optically active 1-phenylethylamine were used to form diastereomeric complexes i.e., (-1-)- and ( —)-trans-dichloro(ethyl p-tolyl sulfoxide) (1-phenylethylamine) platinum(II). Both enantiomers of 6 were obtained in optically pure form. Diastereomeric platinum complexes formed from racemic methyl phenyl (and three para-substituted phenyl) sulfoxides and d-N, N-dimethyl phenylglycine have been separated chromatographically on an analytical column L A nonaromatic example, cyclohexyl methyl sulfoxide, did not resolve. [Pg.57]


See other pages where Platinum dichloro complex is mentioned: [Pg.193]    [Pg.693]    [Pg.725]    [Pg.292]    [Pg.301]    [Pg.420]    [Pg.329]    [Pg.12]    [Pg.207]    [Pg.227]    [Pg.204]    [Pg.86]    [Pg.91]    [Pg.5293]    [Pg.141]    [Pg.685]    [Pg.685]    [Pg.60]    [Pg.61]    [Pg.432]    [Pg.4518]    [Pg.175]    [Pg.404]    [Pg.297]    [Pg.322]    [Pg.61]    [Pg.239]    [Pg.76]    [Pg.747]    [Pg.57]    [Pg.293]    [Pg.711]    [Pg.821]    [Pg.16]    [Pg.427]    [Pg.201]    [Pg.536]   
See also in sourсe #XX -- [ Pg.157 ]




SEARCH



Platinum dichloro

© 2024 chempedia.info