Platinum-containing polymers synthesis

A major effort at utilizing the platinum-containing polymer itself as a drug is the mainchain incorporation of platinum based on the de novo synthesis of the polymer structure from specified monomers, as no presynthesis of carrier polymer is required. The preparative approach is exemplified by the polymerization of tetra-chloroplatinate(II) dianion with diamines and other nitrogen-containing compounds. 

Tanase et al. described the synthesis of platinum-containing organometallic rigid-rod polymers 29.75 These polymers were prepared by reacting [Pt3(p,-dpmp)2(XylNC)2](PF6)2 with... 

Scheme 30.13 Synthesis of a hyperbranched polymer from a platinum-containing acetyUde monomer.

Malik, Duncan, Tomalia, and Esfand [29] reported the use of a variety of amine and acid-containing polymers that chelated platinum forming cisplatin derivatives. They also reported the synthesis of similar dendritic-antineoplastic drugs using vanadocene dichloride. The structure from the poly(propyleneimine) dendrimers contains units are shown in (5) and (6). 

Molecular design and precision synthesis of silicon-containing polymers are described. Polymerizations of substituted silacyclobutanes by phenyllithium and platinum complexes gave poly(carbosilane)s of head to tail regular structure. However, extensive chain transfer seems to have occurred in the polymerization by platinum complexes. 

Anisotropic bimetallic nanoparticles can also be synthesized by radiolysis. Indeed, /-irradiation of an aqueous solution containing silver and platinum metal ions and a polymer (PVA), at dose rates lower than 0.5 kGy.h , led to the synthesis of wire-like Ag-Pt structures with lengths up to 3.5 pm and diameters between 3 and 20 nm.ii7... 

The development of nanocomposites containing metal particles may be very rewarding since such materials can be useful in catalysts, an optical and electronic devices. Figure 16.18 shows the schematic diagram of the method of synthesis. The polymers used in this material were poly(4-methyl-l-pentene) and poly(te-trafluoroethylene). Dimethyl(cyclooctadiene)platinum(II) was used as the metal precursor. The metal precursor was dissolved in supercritical liquid carbon dioxide... 

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