Platinum compounds synthesis

Platinum compounds, 79 654-658. See also Platinum- group metal compounds synthesis of, 79 657 uses for, 79 657... 

Salts of [ ihalf-sandwich compounds 2-(ligand) -c/oxo-2,l-MCBioHii, but their potential as precursors is demonstrated in the synthesis of rhenium and platinum compounds. Thus salts of the dianion [2,2,2-(CO)3-c/oxo-2,l-ReCBioHnf have been prepared by... 

While apparently no metallasilsesquioxane complexes of nickel and palladium have yet been prepared, several literature reports have appeared on platinum compounds containing silsesquioxane ligands. Abbenhuis reported the synthesis and characterization of three platinum(II) complexes stabilized by the chelating diphosphine ligand dppe (= 1,2-bis(diphenylphosphino)ethane) as outlined in Scheme 63. ... 

These compounds do not represent a wide ranging class of complexes for platinum. The synthesis of monomeric sulfato platinum complexes is represented in equations (485) and (486).1636 The complexes are characterized by v(S=0) bands in the 1100-1300 cm-1 region. 

Synthesis. The most important starting materials for platinum compounds are potassium tetrachloroplatinate(II) [100025-98-6], K fPtClJ, and... 

Fig. 4. Possible role of mismatch repair in the cytotoxicity of cisplatin. A) During replicative bypass, a mismatch is incorporated across from the cisplatin-DNA adduct. This compound lesion is bound by the mismatch repair proteins, which cut the DNA on the strand opposite the platinum. Repair synthesis would reproduce the same mismatch, resulting in a futile cycle and possibly the accumulation of DNA strand breaks which would activate apoptosis. B) Alternatively, the mismatch repair complex can recognize the cisplatin-DNA adduct alone and generate a signal that triggers apoptosis.

The success of cisplatin and carboplatin in treating cancer, combined with the intrinsic and acquired resistance of many tumors to traditional platinum chemotherapy, has generated considerable interest in developing next-generation platinum drugs. Since the discovery of the antitumor activity of cisplatin, researchers have reported the synthesis, characterization, and antitumor activity of thousands of platinum compounds [1] [2]. The previous two chapters in this section describe the promising activity of novel multi-nuclear Ptn and orally active PtIV complexes [3] [4],... 

Armes et al. [49] have reported the use of pH-responsive microgels based solely on 2-(diethylamino)ethyl methacrylate (DEA) as colloidal templates for the in situ synthesis of Pt nanoparticles (PtNPs). The swollen microgels can be used as nanoreactors efficient impregnation with PtNPs can be achieved by incorporating precursor platinum compounds, followed by metal reduction. Addition of platinic acid, H2PtCl6, to the latex particles causes the protonation of the tertiary amine... 

The discovery, ca. 1968, by B. Rosenberg, that the cis isomer has anti-tumor activity stimulated the synthesis and screening of over 2000 different types of complexes with different amines and anionic ligands. Platinum compounds are among the most effective medications for the treatment of advanced cancer PtCl2(NH3)2 ( Cisplatin ) is mainly used for the treatment of testicular and ovarian cancer. One of its drawbacks are the severe toxic side-effects which may be related to the facile hydrolysis of Cl ligands under physiological conditions ... 

This approach is especially useful for the synthesis of organopalladium and -platinum compounds. These oxidation-reduction reactions proceed via initial insertion of the transition metal into the carbon-mercury bond and subsequent loss of mercury ... 

Harder HC, Rosenberg B. Inhibitory effects of anti-tumor platinum compounds on DMA, RNA,and protein synthesis In mammalian cells in vitro. Int J Cancer 1970 6 207-16. 

Reaction of hydroxylic compounds with butadiene has been studied with palladium compounds. A common feature is the dimerization of butadiene with incorporation of functional groups from alcohols (270). l-Methoxyoctadiene-2,7 was obtained from butadiene and methanol in the presence of Pd(maleic anhydride)(PPh3)2 (273). Complex Pt(PPh3)4 has also been used, although platinum compounds were less effective. Octadienyl esters were obtained from butadiene and acetic acid in the presence of Pd(acac)2 and either PPh3 or P(OPh)3 (294). Palladium complexes were effective for the synthesis of jS,y-unsaturated esters from butadiene, methanol, and CO. The favored mechanism involved addition of a hydropalladium complex to butadiene to give an allylpalladium intermediate (46). 

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