Platelet cells

These actions of aspirin are thought to result from its abiHty to reduce the production of prostaglandin formed by platelet cells without appreciably... 

Hartwig, J. H., Bokoch, G. M. etal. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82 643-653,1995. 

Olas B, Wachowicz B, Saluk-Juszczak J, Zielinski T, Kaca W, Buczynski A. 2001. Antioxidant activity of resveratrol in endotoxin-stimulated blood platelets. Cell Biol... 

Hager ED, Dziambor H, Hohmann D, Winkler P, Strama H. Effects of lithium on thrombopoiesis in patients with low platelet cell counts following chemotherapy or radiotherapy. Biol Trace Elem Res 2001 83(2) 139 18. 

Only niacin offers benefits in regard to newly determined, independent risk factors for the development and progression of heart disease and the incidence of heart attacks and strokes. It lowers levels of a particularly nasty variant of LDL termed lipoprotein(a). The vitamin improves the balance of the hormonelike substances called prostaglandins, with the detrimental thromboxane falling and the protective prostacycline going up. Activity of blood platelets, cells involved in the clotting process, decrease, resulting in fewer clots that can lead to heart attacks. 

Thrombocytes (platelets) Cells that help form blood clots... 

Oliver, A., Crowe, J., and Crowe, L. Lipid phase behavior and stabilization of domains in membranes of platelets, Cell Biochem. Biophys., 40,123, 2004. 

The thromboxanes are also derivatives of arachidonic acid. They differ from other eicosanoids in that their structures have a cyclic ether. Thromboxane A2 (TXA2), the most prominent member of this group of eicosanoids, is primarily produced by platelets (cell fragments in the blood that initiate blood clot formation). 

Inhibiting P-selectin may prevent not only ischemia reperfusion injury but also the subsequent clotting events that can re-occlude a vessel that s just been opened. PSGL-1 binds to a selectin-P subtype on platelet cells, causing red blood cells to stick to leukocytes and create blood clots. 

The adhesion step refers primarily to the platelet-subendothelial interaction that occurs when platelets initially adhere to the sites of blood vessel injury (Fig. 45.1). Blood vessel injury exposes collagen, subendothelial matrix-bound vWF, and other matrix components. vWF is a protein synthesized in endothelial cells and megakaryocytes, and is located in the subendothelial matrix, in specific platelet granules, and in the circulation bound to Factor Vlll. The platelet cell membrane contains glycoproteins (GPs) that bind to collagen and to vWF, causing the platelet... 

Another example of a prostanoid receptor being coupled to an Np-like protein occurs with a thromboxane A2 receptor in platelet cells. Thromboxane A2 can cause the turnover of inositol phosphates in platelets through a mechanism which is insensitive to pertussis toxin in addition, thromboxane A2 functions in platelets to attenuate hormone-dependent cAMP formation by a process inhibited by pertussis toxin and probably involving N/. Presumably, there are separate platelet TXA2 receptors coupled to N and Nj, but only one TxA2 binding activity has been identified in platelets. ... 

Root, R, Shskovic, I., Mutus, B. Platelet cell-surface protein disulfide-isomerase mediated 5-nitrosoglutathione consumption. Biochemical Journal, 2004, 382, 575-580. 

As particles are examined one by one a highly resolved distribution by number can be established. The number of particles recorded in each size class can be readily totaled to form a distribution by volume. If the total volume of suspension fluid passing through the aperture is also recorded then the number of particles per unit volume of suspension can also be obtained. This feature has provided an important tool in medicine in being able to count red, white, and platelet cells from blood samples. 

Under physiological conditions, conversion of prothrombin to thrombin by X appears to require binding to a cell membrane. V is the platelet cell membrane receptor for X, and it increases the proteolytic activity of the latter. 

CD-62P P -selectin, a cell adhesion molecule found on active platelet cell membranes CL-20 Energetic materials lexicon for 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaiso-wurtzitane, a powerful chemical explosive cN/tex The unit Centi Newton per tex... 

YIGSR, IKVAV (from laminin) REDV (endotheUal-specilic) Adhesion molecules Intercellular adhesion molecule-1 (ICAM-I) Vascular cell adhesion molecule-1 (VCAM-l) Platelet cell adhesion molecule-1 (PCAM-1)... 

Applicattoiis of the device include fractionation of blood plasma, isolation of enzymes from muscle extracts and the separation and concentration of platelet cells from red blood. 

LTB4 chemotactic agent for neutrophils, eosinophils, e.g. increase degranulation of platelets, cell surface receptors and adherence of polymorphonucleocytes to receptor cells... 

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