Plasma, proteins originating from

To conclude, we have developed a strategy which combines LC-MALDI-MS and nanoLC-MS/MS in order to identify proteins originating from ID gel with a high coverage compatible with plasma membrane study (CD98, CD71, CD44). 

Cystatin C (Formerly Post-y-globulin, y-Trace Protein). Cystatin C is a new parameter in a spinal fluid and serum (plasma), originating from glial elements and belonging to so-called trace proteins. Its increasein CSF is considered to be a marker of tissue destruction. Assessment of cystatin C in serum (plasma) is a marker of renal glomerular filtration. 

The Human Proteome Project (HUPO, www.hupo.org) initiated the Plasma Proteome Project (PPP) in 2002, and numerous laboratories have contributed to this ambitious project of deciphering all proteins contained in the human plasma. Plasma, the soluble component of the human blood, is believed to harbor thousands of distinct proteins that originate from a variety of cells and tissues through either active secretion or leakage from blood cells or tissues. For the reasons described above, HUPO recommends use of plasma instead of serum, with EDTA (or citrate) for anticoagulation and standardized sample preparation. HUPO proposes combinations of serum depletion, fractionation procedures, and MS/MS technologies, with explicit... 

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