Plasma glucose response

Fig. 8 Three-way crossover trial in 16 healthy volunteers comparing one inhalation of a 3 mg blister of insulin (B) three inhalations of a 1 mg blister of insulin (A) and an injection of subcutaneous insulin, 0.15U/kg of body weight (approximately 10 units, ). Plasma insulin response (A) and plasma glucose response (B). (From Ref with permission from the copyright holder.)...

Fig. 11-6 Different plasma glucose response in two different patients after a meal one who is insulin tolerant and one who is insulin intolerant, for example, as occurs in non-insulin dependent diabetes mellitus (NIDDM).

Table 1. Effect of dry period feeding level on plasma glucose responses to glucose challenge at 7 d pre partum. 

Table 1. Plasma glucose response to intravenous tolbutamide (as percentage of basal values) before and after 7 days of clofibrate administration in 6 patients with mild diabetes...

Perley M, Kpnis D (1967) Plasma insulin responses to oral and intravenous glucose studies in normal and diabetic subjects. J Clin Invest 46 1954—1962... 

Armario A, Marti 0, Molina T, de Pablo J, Valdes M. (1996). Acute stress markers in humans response of plasma glucose, cortisol, and prolactin to two examinations differing in the anxiety they provoke. Psychoneuroendocrinology. 21(1) 17-24. 

P-cells are those present in the Islets of Langerhans in the pancreas that secrete insulin in response to an increase in the plasma glucose concentration. 

During treatment initiation and dose titration, use 1 hour postprandial plasma glucose to determine the therapeutic response to acarbose and identify the minimum effective dose for the patient. Thereafter, measure glycosylated hemoglobin at intervals of about 3 months. 

Schmidt. M.E., Oshinsky, R.J., Kim, H.G., et al. Cerebral glucose metabolic and plasma catecholamine responses to the alpha (2) adrenoceptor antagonist ethoxyidazoxan given to healthy volunteers. Psvchopharmacologv 146(2), 119-127, 1999. ... 

Prince RL, Larkins RG, Alford FP. The effect of acetylsa-licylic acid on plasma glucose and the response of glucose regulatory hormones to intravenous glucose and arginine in insulin treated diabetics and normal subjects. Metabolism 1981 30(3) 293-8. 

Q4 In type 2 diabetes there is a reduction in the responsiveness of beta-cells (/1-cells) to plasma glucose levels (which might be due to a reduction in the number of (6-cells or their abnormal function) and an increase in the secretion of glucagon. Many patients with this condition show resistance insulin. Insulin resistance is defined as a suboptimal response to insulin in insulin-sensitive tissues (liver, muscle and adipose tissues). Insulin resistance is increased by obesity, inactivity and age. Obesity and insulin resistance coexist in approximately 60% to 80% of patients with type 2 diabetes in the West. In approximately 10% to 40% of patients with type 2 diabetes, amyloid deposits have been found in the islet tissues of the pancreas. Interestingly, the presence of amyloid correlates positively with the age of the patient and the duration and severity of the disease. 

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