Fibrinogen plasma concentration

Scrutton, M. C., Ross-Murphy, S. B., Bennett, G. M., Stirling, Y., and Meade, T. W. (1994). Changes in clot deformability - a possible explanation for the epidemiological association between plasma fibrinogen concentration and myocardial infarction. Bbod Coagul. Fibrinolysis 5, 719-723. 

Table V shows that the amount of adsorption onto Silastic from plasma is significantly depressed below its saturation value measured in buflFer presumably because of competition from other components of the plasma. The diflFerence in adsorption from the two plasma pools may result from the increased fibrinogen concentration in one pool which would allow more eflFective competition for adsorption onto Silastic and result in enhanced adsorption. Since the adsorption of fibrinogen onto poly (HEMA)/Silastic from plasma is not so greatly depressed relative to adsorption from buflFer (see Table V), an increase in plasma fibrinogen concentration might not have so large an eflFect on adsorption onto poly-(HEMA)/Silastic as it apparently does on adsorption onto Silastic itself.

Immediately after an injury, there is loss of fluid to extravascular tissue with a resulting decrease in plasma volume. If the decrease is enough to impair circulation, glomerular filtration is diminished. Diminished renal function leads to the accumulation of urea and other end products of protein metabolism in the circulation. In burned patients, serum total protein concentration falls by as much as 0.8g/dL became of both loss to extravascular spaces and catabolism of protein. Serum aj-, tt2-, and y-globulin concentrations increase, but not enough to compensate for the reduced albumin concentration. The plasma fibrinogen concentration responds dramatically to trauma and may double in 2 to 8 days after surgery. The concentration of C-reactive protein rises at the same time. 

Fibrinogen, Another abnormality of blood with the onset of scurvy is the marked increase of plasma fibrinogen concentration reported both in the guinea pig (M14) and the monkey (S2). 

Several mechanisms have been suggested whereby an increase in plasma fibrinogen concentration may be linked to CHD. These include the involvement of fibrinogen and fibrin in the evolution of the atheromatous plaque through fibrin deposition and in... 

The final fibrinogen concentration in this experiment was 1.50 mg/ml. The citrated plasma had been made 1.5 years prior to its use in this experiment and had been stored frozen in polyethylene bottles. 

Naftidrofuryl is a complex acid ester of diethylaminoetha-nol, with direct vasodilatory properties and antagonistic effects on 5-HT (via 5-HT2 receptors) and bradykinin. It also causes an intracellular increase in ATP concentrations, improves cellular oxidative metabolism (by activating succinate dehydrogenase), and reduces blood and plasma viscosity and fibrinogen concentrations. 

Routine Blood Tests. Complete blood counts (CBCs) (I), platelet counts (2), plasma hemoglobin (3), and fibrinogen concentration (4) were all done by standard methods modified by us for goat blood. 

Materials. Bovine plasma albumin (Lot. 12F-9365) and bovine plasma y-globulin (Lot. 116C-0147), 99 %electrophoretically pure, were purchased from Sigma Chemical Co., and bovine plasma fibrinogen (Lot. 26), 95% clottable, was purchased from Miles Laboratory Inc. The concentration of these plasma proteins was determined by spe-ctrophotometiy, and their absorption coefficients were taken to be as follows =6.67 for albumin (a) =11.2 for globulin (S) ... 

Figure 6.10 Effect of streptokinase (SK) on fibrinogen concentration and platelet aggregation induced by ADP in platelet-rich plasma. Platelets were incubated with streptokinase for 1 minute prior to the addition of ADP, lfimo L and aggregation monitored by light transmission. Samples for fibrinogen were collected in aprotinin to prevent continued lysis. The fibrinogenolytic and proaggregatory effects of streptokinase were concentration dependent and were inhibited by aprotinin and e-aminocaproic acid (e-ACA)...

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