Plaques, in Alzheimer’s disease

D Andrea MR, Nagele RG, Wang HY, Peterson PA, Lee DH (2001) Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer s disease. Histopathology 38(2) 120-134... 

Gouras GK, Almeida CG, Takahashi RH (2005) Intraneuronal Abeta accumulation and origin of plaques in Alzheimer s disease. Neurobiol Aging 26(9) 1235-1244 Gray CM, Singer W (1989) Stimulus-specific neurontil oscillations in orientation columns of cat visual cortex. Proc Natl Acad Sci USA 86 1698-1702 Greengard P (1972) Adenosine 3 5 -cychc monophosphate as a mediator in the action of neurohumoral agents. Biochem J 128 75-80... 

Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Ome J, Janus C, Maiiash A, Kuskowski M, Hyman B, Hutton M, Ashe KH (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science 309 476-481 Sayre LM, Perry G, Harris PL, Liu Y, Schubert KA, Smith MA (2000) In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer s disease a centrtil role for boimd transition metals. J Neurochem 74 270-279... 

Nagele RG, Wegiel J, Venkataraman V, Imaki H, Wang KC, Wegiel J (2004) Contribution of glial cells to the development of amyloid plaques in Alzheimer s disease. Neurobiol Aging 25 663-674. 

Jefferies WA, Food MR, Gabathuler R, Rothenberger S, Yamada T, et al. 1996. Reactive microglia specifically associated with amyloid plaques in Alzheimer s disease brain tissue express melanotransfer-rin. Brain Res. 712 122-26... 

Highly lipophihc fluorescent molecules represent the last class of compounds that will be discussed in this section. The compound FDDNP [167, 168], which binds with high affinity to Ay91-40 fibrils in vivo was shown readily to cross the BBB due to its high lipophihcity. Human PET studies were performed, and FDDNP was shown to localize in regions known to develop plaques in Alzheimer s disease [167]. 

Agdeppa, E.D., Kepe, V, Liu, J., Flores-Torres, S., Satyamurthy, N., Petrie, A., Cole, G.M., Small, G.W., Huang, S.C., and Barrio, J.R. (2001) Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthyl-ethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer s disease, J Neu-rosci 21, RC189. 

Araujo, D.M. and Cotman, C.W. (1992b) Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer s disease. Brain Res. 569 141-145. 

In some cases, aggregation of p-sheet peptides is an undesired feature. This is particularly tme for fibril formation of p-amyloid peptide, the primary component of amyloid plaques in Alzheimer s disease. Burkoth et investigated the possi-... 

Fluorine-18 radiolabeled heterocycles as PET tracers for imaging p-amyloid plaques in Alzheimer s disease 13CTM909. 

TGF-p induces TIAFl self-aggregation via type II receptor-independent signaling that leads to generation of amyloid p plaques in Alzheimer s disease. Cell Death Dis. 2070 l(12) ell0. 

I. Ferrer, R. Blanco, M. Carmona, B. Puig, R. Ribera, M. J. Rey and T. Ribalta, Prion protein expression in senile plaques in Alzheimer s disease, Acta NeuropathoL, 2001, 101(1), 49-56. 

Gouras GK, Almeida CG, Takahashi RH (2005) Intraneuronal Abeta accumulation and origin of plaques in Alzheimer s disease. Neurobiol Aging 26 1235-1244... 

Benveniste, H. Einstein, G. Kim, K. R. et al. Detection of neuritic plaques in Alzheimer s disease by magnetic resonance microscopy. 

Sayre, L. M. Perry, G. Harris, P. L. et al. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer s disease a central role for bound transition metals. J. Neurochem. 2000, 74,270-279. 

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