Pituitary tumor cells

NakayamaK, IshidaN, Shirane Metal 1996 Mice lacking p27(Kipl) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85 707-720... 

Norfleet AM, Thomas ML, Gametchu B, Watson CS (1999) Estrogn receptor-a detected on the plasma membrane of aldehyde-fixed GH3/B6FIO rat pituitary tumor cells by enzyme-linked immunocytochemistry. Endocrinology 140 3805-3814... 

Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., I., H., Loh, D., and Nakayama, K. (1996). Mice lacking p27 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, 707-720. 

Drummond AH, Raeburn CA The interaction of lithium with thyrotropin releasing hormone-stimulated lipid metabolism in GH3 pituitary tumor cells. Biochem J 224 129-136, 1984... 

Type II deiodinase activity is low in unsupplemented tissue homogenates but is stimulated by DTT [71-74,82,83] and to a lesser extent also by GSH [72]. The DTT concentrations required for maximal enzyme stimulation in the CNS and pituitary seem higher than in BAT and also than those necessary for the type I deiodinase in liver and kidney. Kinetic analysis of the deiodination of varying substrate (T4, rT3) concentrations at different cofactor (DTT) levels have indicated a sequential reaction mechanism for the type II deiodinase [73,82,83]. This is very suggestive of the formation of a ternary enzyme-substrate-cofactor complex in the catalytic process [82], The physiological cofactor of the type II deiodinase has not been identified but it has been observed that GSH depletion with diamide or diethylmaleate impairs T4 to T3 conversion in GH3 pituitary tumor cells [93]. 

Energy-dependent, carrier-mediated uptake of thyroid hormone has been demonstrated in a variety of other cell types, including fibroblasts [109,110], pituitary tumor cells [111] and muscle cells [112]. In addition to the uptake processes in the plasma membrane, indirect evidence has been reported recently for active transport of T3 between subcellular compartments, i.e., from the cytoplasm to the nu-... 

Florio T, Pan MG, Newman B, Hershberger RE, Civelli O, Stork PJ (1992) Dopaminergic inhibition of DNA synthesis in pituitary tumor cells is associated with phosphotyrosine phosphatase activity. J Biol Chem 267 24169-24172. 

Bulatov AA, Martynov AV, Grigor ian AL, Komolov IS. Molecular forms of human growth hormone and prolactin, secreted by cultured pituitary tumor cells. Biokhimiia 1995 60 1637-46. 

Internalization of the radioiodinated somatostatin analog ( -Tyr ) octreotide by mouse and human pituitary tumor cells increase by unlabeled octreotide. Endocrinology 136 3698-3706... 

Banerjee, S., Saxena, N., Sengupta, K., and Baneijee, S.K., ITAlpha-eshadiol-induced VEGF-A expression in rat pituitary tumor cells is mediated through ER independent but PI3K-Akt dependent signaling pathway, Biochem. Biophys. Res. Commun., 300,209-215,2003. 

Banerjee, S.K., Zoubine, M.N., Tran, T.M., Weston, A.P., and Campbell, D.R, Overexpression of vascular endothehal growth factorl64 and its co-receptor neuropilin-1 in estrogen-induced rat pituitary tumors and GFI3 rat pituitary tumor cells, Int J. Oncol, 16,253-260,2000. 

Reisine, T.D., Zhang, Y.-L. and Sekura, R. (1983). Pertussis toxin blocks somatostatin s inhibition of stimulated cAMP accumulation in anterior pituitary tumor cells. Biochem. Biophys. Res. Commun., 115, 794-799... 

Spindler, S. R., Mellon, S. H., and Baxter, J. D. (1982). Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells. J. Biol. Chem. 257 11627-11632. 

Kohler, P. O., L. A. Frohman, W. E. Bridson, T. Vanha-Perttula, and J. M. Hammond. 1969. Cortisol induction of growth hormone synthesis in a clonal line of rat pituitary tumor cells in culture. Science, 166 633. 

Wozniak AL, Bulayeva NN, Watson CS. Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-a mediated Ca++ fluxes and prolactin release in GH3/B6 pituitary tumor cells. Environ Health Perspect 2005 113 431-439. 

Mains, R. E., and Eipper, B. A., 1978, Coordinate synthesis of corticotropins and endorphins by mouse pituitary tumor cells, /. Biol. Chem. 253 651. 

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