Pituitary function regulation

Ben-Jonathan N, Laudon M, Garris PA (1991) Novel aspects of posterior pituitary function regulation of prolactin secretion. Front Neuroendocrinol 72 231-277. 

Contraceptives. Figure 1 Regulation of hypothalamic and pituitary function by ovarian steroid hormones. 

Fink G (2000) Neuroendocrine regulation of pituitary function general principles. In Conn PM, Freeman ME (eds) Neuroendocrinology in physiology and medicine. Humana, Totowa, NJ, pp 107-134... 

Other Hormones. Pituitary hormones regulate the function of many other endocrine glands, and hypophysectomy in male rats results in a decrease in the activity of xenobiotic metabolizing enzymes. Administration of adrenocorticotropic hormone (ACTH) also results in a decrease of those oxidative enzyme activities that are gender dependent. In contrast, ACTH treatment of female rats causes an increase in aminopyrine /V-dcmcthylasc but no change in other activities. 

Aronin N, Coslovsky R, Leeman SE (1986) Substance P and neurotensin their roles in the regulation of anterior pituitary function. Ann Rev Physiol 75 537-549. 

A review by Rase . summarizes. studies on the effects of certain hormones on vitamin B(, nutrition in humans, on the biochemical interrelationship between steroid hormones and pyridoxal phasphate-dependent enzymes, and on the role of vitamin B(, in regulating hypothalamus-pituitary functions. Some of these studies have important clinical implications. The use of estrogen-containing oral contraceptives has been investigated as a factor leading to an abnormality of tiyptophan metaboli.sm. This abnormality resembles dietary vitamin B deficiency and responds favorably to treatment with the vitamin. For some time, there has been clinical interest in the relationship between certain hormones and vitamin B function because abnormal urinary excretion of tiyptophan metabolites was observed during pregnancy and in patients with hyperthyroidism. 

The pituitary gland regulates virtually every endocrine gland and is often called the "master gland." It is divided anatomically and functionally into an anterior and a posterior lobe. 

The hypothalamus secretes releasing and inhibitory substances into the anterior pituitary vasculature, thereby regulating anterior pituitary function. Pituitary secretions are also controlled by feedback control via circulating hormones. Endocrine systems influenced by the anterior pituitary are ... 

Iodine has a direct effect on thyroid function and growth, independent of pituitary TSH regulation in vivo, as well as in vitro. Because the action of iodine is inhibited by compounds inhibiting peroxidase activity such as MMI or PTU, and thyroid hormones have no direct effect on thyroid growth and function, other... 

Lit and PSH are glycoprotein hormones produced by the anterior pituitary. They regulate gonadal function. 

Solid-phase Zincke reaction was applied for the search of activators of the cystic fibrosis transmembrane conductance regulator protein. On the other hand, the tripeptide TRH (pGlu-His-Pro-NH2) was shown to be a hypothalamic releasing factor for the regulation of pituitary function. A solid-phase Zincke reaction was used to prepare analogues of TRH having the central histidine replaced with a 1,4-dihydropyridine unit (such as 48). Compound 48 was expected to cross the hydrophobic blood-brain barrier (BBB) but to be trapped within the central nervous system upon oxidation to the hydrophilic pyridinium form. 

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