2-Methyl-2-piperidino

The electron-rich diene, 1 -piperidino-2-methyl-l,3-pentadiene (48), reacted with the thiirene 1,1-dioxide (31a) in boiling benzene to afford 61% of the dihydrobenzene derivative (50) via (49) (Scheme 21) <84JOC1300>. [Pg.201]

H r CXn ch2 s cooc R- H R = CH3 R-OCjH5 5 HN(C4H9)2 HN(C6Hn)2 hv) 40%iges CHjO/HjO 20", 3 h l-( Dihutylamino-methyl)-2-( ethoxyearbonyl-methyl-thio) -... l-( Dicyclohexylamino-methyl) -2- ( ethoxy carbonyl-methyl-thio)-5-methyl-... 5-Ethoxy-2- ( ethoxycarbonyl-methylthio)-l-(piperidino-methyl)-... 33,5 31 40 237-239 177-179 118-119 445... [Pg.345]

Phenyl-4-(piperidino-methyl)-5-ihiono-4,5-dihydro-1,2,4-oxadiazol, 37% Schmp. 122 ... [Pg.504]

Nitromethyl-l-oxo-cycloalkane bzw. 1-Nitromethyl-cycloalkene lassen sich mit Pyrro-lidinen oder (S,)-2-Methoxymethyl-pyrrolidin bzw. -piperidin in Acetonitril bei 20° unter Austausch der Nitro-Gruppe in guten Ausbeuten in 2-(Pyrrolidino-methyl)-l-oxo-cycloalkane3 bzw. l-(Piperidino-methyl)-cycloalkene8 uberfuhren (s.a. S. 378) ... [Pg.376]

Butyl-ethyl- -ethylester XII/1, 255 Butyl-ethyl- -propylester XII/1, 257 Butyl-(methoxycarbonyl-piperidino-methyl)- -ethylester E2, 206... [Pg.1019]

Ammoninm (Piperidino-methyl)-trimethyl- -bromid E16a, 1008 (N-Aminomethylier.) Formamidinium N,N -Dimethyl-N,N -dipropyl-(iodid) E5, 94 (N-Alkylier.) N,N,N, N -Tetraethyl- (methylsulfat) E5, 90 (OR - NR2) Piperidinium l-(Dimethylamino-methyl)-l-methyl- -bromid E16a, 1008 (N-Aminomethylier.)... [Pg.685]

E21d, 4070 (Oxo - H/OH) Peroxid tert.-Butyl-(piperidino-methyl)- E13/1, 615 (NH + CH20 + R-O-OH) Propansaure 2-Hydroxy-2-methyl- -diisopropylamid E19d, 661 (H - Li/+ Keton)... [Pg.825]

Isothiocyanat [(4-Chlor-phenyl-imino)-piperidino-methyl]- E4, 1263 (Cl -> NCS)... [Pg.1135]

Sulfan Carbamidino-(phenylimino-piperidino-methyl)- (Hydrochlo-rid) E4, 1017 (Thioharnstoff-Der, + R-NH-CN)... [Pg.1168]

Handling, Storage, and Precautions (S)-l-methyl-2-(piperidino-methyl)pyrrolidine and its derivatives can be synthesized from L-proline. Methods for the preparation are described in refs lb and 2b. Properties of chiral diamines and synthetic intermediates are shown in refs lb, 2d, and 3b. [Pg.428]

Ebenfalls unter Entalkylierung verlauft die Bildung von 2-Mercapto-l,3-thiazol (86%) aus 3-(Piperidino-methyl)-2,3-dihydro-l,3-thiazol. Die abgespaltene Piperidinomethyl-Gruppe wird auf ein zweites Molekiil des Eduktes ubertragen1090. [Pg.197]

Piperidin Ra-Co 1) Enamin-Bildung 140-160° in 100 60 3-(Piperidino-methyl)-indan 52 1... [Pg.425]

H0 O-CH=N0H CN- RaNi Athanol/Ammoniak 4,2 20 4-Aminomethyl-2-piperidino- methyl-phenol 50 4... [Pg.545]

Ox o-2-(2,2-diphenyl- 1-methoxycarbonyl- vinyl)-1-phenyl- 713 1-Oxo-2-methyl- 205 l-Oxo-2-[pyridyl- 2)-methylen]- 464 3-(Piperidino-methyl)- 425... [Pg.863]

C HieBrII lO-Biom-2-methyi-9-piperidino< methyl-anthiBoen 20II18,... [Pg.1432]

A soln. of phenylacetylene in anhydrous tetrahydrofuran added dropwise during 0.5 hr. to a soln. of ethylmagnesium bromide prepared from ethyl bromide and Mg in the same solvent, stirred 2 hrs. at 50, then a soln. of piperidino-methyl butyl ether in the same solvent added, and refluxed 3 hrs. with stirring l-phenyl-3-piperidino-l-propyne. Y 76%. F. e., also from cyclic compounds, s. I. Iwai and Y. Yura, Chem. Pharm. Bull. 11, 1049 (1963). [Pg.444]

Other Radioprotective Chemicals. The bis-methylthio- and methylthioamino-derivatives of 1-methylquinolinium iodide and l-methylpyridinium-2-dithioacetic acid provide reasonable protection to mice at much lower doses than the aminothiols, which suggests a different mechanism of action (139). One of these compounds, the 2-(methylthio)-2-piperidino derivative of the l-methyl-2-vinyl quinolinium iodide (VQ), interacts with supercoUed plasmic DNA primarily by intercalation. Minor substitutions on the aromatic quinolinium ring system markedly influence this interaction. Like WR-1065, VQ is positively charged at physiological pH, and the DNA-binding affinities of VQ and WR-1065 appear to be similar. [Pg.493]

Halo-substituted 3-hydroxypyridazin-6(lFf)-ones react in some instances by cine substitution. For example, 4-chloro-l-methyl-2-phenylpyridazin-6(lFf)-one, when treated with piperidine, yields a mixture of the corresponding 4- and 5-piperidino isomers in nearly equal amounts. [Pg.25]

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